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c/tapering·posted 23 days ago by u/aleksi_lehtinen

anyone else notice regain kicking in around week 20

Discussion Clean Column ×8

Check-in as promised in the title: anyone else notice regain kicking in around week 20.

There is very little published guidance on stopping specifically, which is exactly why board consensus here should carry less weight than usual and a clinician conversation should carry more.

Nothing on this board is a taper schedule, and no member can write one for another. What can be shared is what people watched and what they observed.

Would rather be corrected in public than confident in private.

565 up / 84 down87% upvoted31 commentsid ukpdh67 Jul 2026

31 comments

23 in this archive, depth 4

best — the order this archive was captured in

u/pavel_halvorsen36 points·22 days ago

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

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u/vial_math_verasyringe math13 points·21 days ago

stretching to ten days then twelve is the pattern people report

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u/osman_eriksen17 points·21 days ago

Push back: that is a taper schedule aimed at another member and this board does not host those.

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u/careful_gradient-1 point·22 days ago

a fortnight of nothing is not evidence that you are fine

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u/rekha_teixeira17 points·21 days ago

Regained most of it over a year and spent that year assuming it was my fault. It was not; it is what the literature describes.

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u/priya_weiss6 points·21 days ago

nobody here can write you a taper schedule

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[deleted]6 points·21 days ago

[deleted]

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u/camila_marchand1 point·20 days ago

stopping abruptly and stopping gradually are different experiences

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u/quarter_dose_queenlow and slow1 point·20 days ago

Stopped for cost reasons. Appetite came back at about week 20, well before the scale moved, exactly as this board said it would.

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u/aleksi_lehtinenOP1 point·20 days ago

regain is the expected outcome and framing it as failure helps nobody

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u/andres_restrepo12 points·21 days ago·edited

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

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u/salma_vasquez6 points·21 days ago

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it.

Agreed — and the exposure lag means the first fortnight tells you almost nothing.

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u/marta_marchand2 points·21 days ago

the habits are what has to carry it afterwards

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u/meera_oyelaran18 points·21 days ago

the withdrawal data is unambiguous and it is not about willpower

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u/elin_varga5 points·21 days ago

Yes — the withdrawal literature is consistent and it is a pharmacological finding, not a moral one.

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u/zeynep_zielinski3 points·21 days ago

Stretching the interval or reducing the dose?

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u/maintenance_mode_maxmaintenance2 points·20 days ago

Stretching the interval or reducing the dose?

This is the sentence that reframes the whole board. Appetite first, scale later.

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u/chidi_vermeulen2 points·20 days ago·edited

Stretching the interval or reducing the dose?

Adding the one process step — write down where you are before you change anything.

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u/camila_marchand2 points·20 days ago

stopping is a plan, not an event

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u/chidi_roos6 points·21 days ago

A written baseline — dose, date, weight, waist, and how appetite feels — taken before any change is what makes the following months interpretable rather than a series of impressions.

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u/honest_syringe_20252 points·20 days ago

coming back later is allowed and it is common

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u/marta_marchand1 point·20 days ago

What are you planning to watch for, and over what period?

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u/lane_watchermod · logistics3 points·20 days ago

A written baseline — dose, date, weight, waist, and how appetite feels — taken before any change is what makes the following months interpretable rath

chidi_roos is right that regain is a documented outcome rather than a character verdict.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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