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c/tapering·submitted 7 days ago by u/camila_marchand

[Trial Data] what the STEP 4 and SURMOUNT-4 withdrawal arms actually showed

Trial Databranch of 6 comments

Slightly embarrassed to be asking this, but: what the STEP 4 and SURMOUNT-4 withdrawal arms actually showed. The habits are what carried it for a while. When they slipped, everything else followed, in that order. Why the first fortnight tells you nothing. With a week-long half-life, exposure declines over several…

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6 comments, started 5 days ago
u/zeynep_weiss9 points·5 days ago

A written baseline — dose, date, weight, waist, and how appetite feels — taken before any change is what makes the following months interpretable rather than a series of impressions.

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u/viktor_kirchner4 points·5 days ago

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

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u/maren_baptista3 points·4 days ago

This. Decide in advance what you are watching for. Deciding in the middle of it is much harder.

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u/ferran_krastev5 points·4 days ago

the withdrawal data is unambiguous and it is not about willpower

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u/vikram_asante5 points·5 days ago

Have you had the conversation with a clinician yet?

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u/priya_weiss4 points·5 days ago

Yes — have the conversation before rather than after. That is the one piece of process advice this board can give.

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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