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c/tapering·posted 16 days ago by u/priya_guerrero

[Discussion] restarting is not failing and we should say that louder

Discussion Cold Box ×2

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking tapering against ApoB for 35 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

672 up / 52 down93% upvoted21 commentsid qouxrk14 Jul 2026

21 comments

15 in this archive, depth 5

best — the order this archive was captured in

u/injection_site_iris-2 points·14 days ago

Maintenance for 17 months now. Weight moves within about 3kg and the dose is a quarter of what it peaked at.

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u/zeynep_zielinski84 points·14 days ago

This is correct. Discontinuation data is real.

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u/viktor_laurent70 points·14 days ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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u/priya_guerreroOP35 points·14 days ago

STEP 1 and SURMOUNT-4 discontinuation arms show regain

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u/micro_bump_mick52 points·14 days ago

appetite return timelines vary appetite return

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u/maintenance_mode_maxMOD61 points·14 days ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/lina_adebayo28 points·14 days ago

This is correct. Discontinuation data is real.

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u/preservative_free_p14 points·14 days ago

What are you comparing it against though?

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u/peptidemeter_pat8 points·13 days ago

Yeah, regain is not a failure.

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u/chain_confirm_cpayments11 points·13 days ago

no shaming people who restart

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u/priya_guerreroOP0 points·13 days ago

Came off after 51 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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[deleted]22 points·14 days ago

[deleted]

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u/katrin_diallo7 points·13 days ago

the 8 week discontinuation arm is the data

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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