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c/tapering·posted 1 year ago by u/valeria_girard

how much of what we believe about tapering actually comes from discontinuation threads

Question Clean Column ×6 Slow Clap ×2

Asking properly rather than in a comment on somebody else’s thread: how much of what we believe about tapering actually comes from discontinuation threads.

A written baseline — dose, date, weight, waist, and how appetite feels — taken before any change is what makes the following months interpretable rather than a series of impressions.

Stopped for cost reasons. Appetite came back at about week 16, well before the scale moved, exactly as this board said it would.

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

That is everything I have. The rest is opinion and I have tried to keep it out.

1,949 up / 70 down97% upvoted55 commentsid if3vy916 Jul 2025

55 comments

21 in this archive, depth 5

best — the order this archive was captured in

u/janek_ferrari228 points·1 year ago

There is very little published guidance on stopping specifically, which is exactly why board consensus here should carry less weight than usual and a clinician conversation should carry more.

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u/arne_amankwah174 points·1 year ago

Careful — interval stretching and dose reduction are different interventions and your post uses them interchangeably.

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u/micro_bump_mick-26 points·1 year ago·edited

Have you had the conversation with a clinician yet?

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u/valeria_girardOP1 point·1 year ago

That is a pause rather than a stop, and the plans for the two are not the same.

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u/taper_off_tabithaMOD130 points·1 year ago

Pointing the clinical part of this at somebody qualified. The experience part can stay here.

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u/appeal_letter_al101 points·1 year ago

Correction: that study measured regain after discontinuation, not loss of effect during treatment. Very different findings.

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u/ismael_varga39 points·1 year ago

This. Decide in advance what you are watching for. Deciding in the middle of it is much harder.

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u/valeria_girardOP23 points·1 year ago

What are you planning to watch for, and over what period?

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u/valeria_girardOP14 points·1 year ago

Small fix — you have described interval stretching and called it a taper. The exposure profiles differ.

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u/adaeze_weiss98 points·1 year ago

Disagree with the framing. Regain is the documented outcome after discontinuation; calling it a personal failure is both wrong and corrosive.

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u/ignacio_silva54 points·1 year ago

Wrote down where I was before changing anything. That single page made the following six months interpretable.

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u/appeal_letter_al25 points·1 year ago·edited

Wrote down where I was before changing anything.

ignacio_silva is right that regain is a documented outcome rather than a character verdict.

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u/appeal_letter_al54 points·1 year ago

Agreed. Appetite is the leading indicator and the scale is the lagging one. Watch the first, not the second.

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u/nora_ramos38 points·1 year ago

How long were you at the dose you are coming off?

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u/ines_boateng22 points·1 year ago·edited

How long were you at the dose you are coming off?

Disagreeing with this bit: stretching and reducing are different things and the post treats them as one.

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u/maintenance_mode_maxmaintenance64 points·1 year ago

Preparing to stop, as described by people here who have done it.

Write down where you are first: dose, date, weight, waist, and an honest note about how appetite feels. That page is what makes the following six months interpretable rather than a fog of impressions.

Decide in advance what you are watching for and over what period — appetite in the first month, weight over three, and a specific threshold at which you would want to revisit the decision. Have the conversation with a clinician before rather than after.

None of that is a schedule. It is a way of arriving at whatever happens next with information rather than with a vague sense of how it is going.

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u/laila_delgado19 points·1 year ago

stopping abruptly and stopping gradually are different experiences

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u/cormac_roos42 points·1 year ago

That reads as advice to stop, which is not something anyone here should be offering.

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u/skip_week_sceptic13 points·1 year ago

write down where you are before you change anything

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u/careful_gradient33 points·1 year ago

Yes — have the conversation before rather than after. That is the one piece of process advice this board can give.

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u/ilias_kaufmann0 points·1 year ago

decide what you are watching for before you stop

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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