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c/tapering·posted 1 year ago by u/naomi_ekstrom

switched from 0.5mg to 1.0mg and early fullness got better, not worse

Regain Slow Clap ×7

switched from 0.5mg to 1.0mg and early fullness got better, not worse. Not a hot take, just something I have not seen said plainly here.

0.5mg and 1.0mg. Those are measured, not estimated, and not rounded up in my favour.

A written baseline — dose, date, weight, waist, and how appetite feels — taken before any change is what makes the following months interpretable rather than a series of impressions.

There is very little published guidance on stopping specifically, which is exactly why board consensus here should carry less weight than usual and a clinician conversation should carry more.

Please do not ask me what dose you should be on. I genuinely do not know and neither does anyone else here.

1,022 up / 194 down84% upvoted36 commentsid fn4pik9 Jan 2025

36 comments

27 in this archive, depth 5

best — the order this archive was captured in

u/rafael_sjoberg-34 points·1 year ago

Nothing on this board is a taper schedule, and no member can write one for another. What can be shared is what people watched and what they observed.

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u/janek_ferrari1 point·1 year ago

How long were you at the dose you are coming off?

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u/cormac_roos1 point·1 year ago

stopping is a plan, not an event

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u/naomi_ekstromOP1 point·1 year ago

What is prompting the decision — cost, supply, side effects, or something else?

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u/maren_baptista1 point·1 year ago

the habits are what has to carry it afterwards

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u/naomi_ekstromOP-40 points·1 year ago

Stretching the interval or reducing the dose?

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u/naomi_ekstrom1 point·1 year ago

Correcting myself upthread: appetite returned at week 24 for me, not the week I posted.

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u/zeynep_zielinski1 point·1 year ago

Push back: that is a taper schedule aimed at another member and this board does not host those.

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u/nayeli_fonseca103 points·1 year ago·edited

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

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u/marta_marchand120 points·1 year ago

Stopped abruptly once and gradually once. The gradual one was easier to interpret because I could see what was changing.

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u/vial_math_verasyringe math34 points·1 year ago

appetite comes back before the weight does

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u/camila_marchand66 points·1 year ago

Yes — the withdrawal literature is consistent and it is a pharmacological finding, not a moral one.

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u/aleksi_lehtinen59 points·1 year ago

Went back on after eight months away. Nobody here made me feel bad about it, which mattered more than I expected.

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u/dizzy_on_standing37 points·1 year ago

Is this a pause or a stop? They are different plans.

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u/naomi_ekstromOP21 points·1 year ago

Correction: that study measured regain after discontinuation, not loss of effect during treatment. Very different findings.

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u/coldchain_karencold chain12 points·1 year ago

stopping abruptly and stopping gradually are different experiences

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u/source_or_silence49 points·1 year ago

Has appetite changed yet, independent of the scale?

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u/maintenance_mode_maxmaintenance39 points·1 year ago

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

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u/chidi_vermeulen12 points·1 year ago

Appetite is the proximal effect and weight is the lagging integrated outcome, which is why watching appetite gives you an earlier and more honest signal.

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u/patient_labslip_log10 points·1 year ago

Have you had the conversation with a clinician yet?

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u/marta_dziedzic6 points·1 year ago·edited

Have you had the conversation with a clinician yet?

Adding the one process step — write down where you are before you change anything.

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u/zeynep_villalobos2 points·1 year ago

Regained most of it over a year and spent that year assuming it was my fault. It was not; it is what the literature describes.

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u/yara_bakken1 point·1 year ago

coming back later is allowed and it is common

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u/marta_marchand4 points·1 year ago

stretching to ten days then twelve is the pattern people report

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u/hana_lehtinen2 points·1 year ago·edited

stretching to ten days then twelve is the pattern people report

Agreed — and the exposure lag means the first fortnight tells you almost nothing.

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u/pavel_halvorsen28 points·1 year ago

Do you have a written baseline from before you started changing anything?

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u/ahmed_cardoso17 points·1 year ago

The habits are what carried it for a while. When they slipped, everything else followed, in that order.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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