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c/tapering·submitted 1 year ago by u/patient_labslip_log

[Discussion] we are measuring regain at the wrong time and calling it noise

Discussionbranch of 9 comments

Posting this as a discussion rather than a claim: we are measuring regain at the wrong time and calling it noise. Preparing to stop, as described by people here who have done it. Write down where you are first: dose, date, weight, waist, and an honest note about how appetite feels. That page is what makes the…

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9 comments, started 1 year ago
u/skip_week_scepticMOD175 points·1 year ago

Removed the taper schedule written for another member. Describe your own experience instead.

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u/neha_mwangi83 points·1 year ago

Removed the taper schedule written for another member.

This is the sentence that reframes the whole board. Appetite first, scale later.

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u/britta_boateng44 points·1 year ago

Small fix — you have described interval stretching and called it a taper. The exposure profiles differ.

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u/nikhil_lindqvist44 points·1 year ago

Correction: that study measured regain after discontinuation, not loss of effect during treatment. Very different findings.

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[deleted]16 points·1 year ago

[deleted]

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u/marisol_kravchenko87 points·1 year ago·edited

Removed the taper schedule written for another member.

Adding the one process step — write down where you are before you change anything.

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u/patient_labslip_logOP32 points·1 year ago

Wrote down where I was before changing anything. That single page made the following six months interpretable.

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u/fabio_lehtinen11 points·1 year ago

This. Decide in advance what you are watching for. Deciding in the middle of it is much harder.

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u/patient_labslip_logOP67 points·1 year ago

write down where you are before you change anything

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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