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c/tapering·posted 3 months ago by u/nikhil_lindqvist

week 34 check-in — 9kg down, reflux manageable, one thing confusing me

Discussion Slow Clap ×9

week 34 check-in — 9kg down, reflux manageable, one thing confusing me. Same spreadsheet I have been keeping since the start, nothing retrofitted.

Pulling the figures out of the title: week 34 and 9kg. All of it is written down as it happened rather than reconstructed.

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

Screenshot none of this. Read the whole thread, including the parts where I am told I am wrong.

0 up / 0 down41% upvoted9 commentsid 1kprco25 Apr 2026

9 comments

9 in this archive, depth 4

best — the order this archive was captured in

u/diego_szabo3 points·3 months ago

Appetite is the proximal effect and weight is the lagging integrated outcome, which is why watching appetite gives you an earlier and more honest signal.

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u/ignacio_silva1 point·3 months ago

Had the conversation with a clinician before stopping rather than after. Considerably easier that way round.

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u/neha_krastev3 points·3 months ago·edited

A written baseline — dose, date, weight, waist, and how appetite feels — taken before any change is what makes the following months interpretable rather than a series of impressions.

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u/careful_gradient2 points·3 months ago

Agreed that returning later is common and it is treated here as ordinary rather than as a defeat.

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u/quiet_reader_991 point·3 months ago

Same. A quiet fortnight after stopping tells you very little; the interesting part starts later.

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u/neha_krastev-13 points·3 months ago

write down where you are before you change anything

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u/maren_baptista1 point·3 months ago

interval stretching is the most commonly described approach here

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u/ilias_kaufmann2 points·3 months ago

There is very little published guidance on stopping specifically, which is exactly why board consensus here should carry less weight than usual and a clinician conversation should carry more.

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u/camila_marchand1 point·3 months ago

Disagree with the framing. Regain is the documented outcome after discontinuation; calling it a personal failure is both wrong and corrosive.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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