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c/tapering·posted 3 months ago by u/nikhil_lindqvist

regain — my 2-week log, condensed into one table

Question

The title is the argument: regain — my 2-week log, condensed into one table. Here is the rest of it.

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

Why the first fortnight tells you nothing.

With a week-long half-life, exposure declines over several weeks after a final dose rather than ending with it. So the first two weeks after stopping are still a tail of the previous state, and the stability people report in that window is not evidence about the months after it.

The reports here are fairly consistent: appetite noticeably different somewhere in the second month, weight following later, and the trajectory strongly influenced by whether the habits from the losing phase survived. That is not a prediction for anybody in particular, and it is not a schedule — it is the shape of what members describe, which is the most this board can honestly offer.

Preparing to stop, as described by people here who have done it.

Write down where you are first: dose, date, weight, waist, and an honest note about how appetite feels. That page is what makes the following six months interpretable rather than a fog of impressions.

Decide in advance what you are watching for and over what period — appetite in the first month, weight over three, and a specific threshold at which you would want to revisit the decision. Have the conversation with a clinician before rather than after.

None of that is a schedule. It is a way of arriving at whatever happens next with information rather than with a vague sense of how it is going.

Corrections welcome, especially the pedantic ones. Pedantry is how this board earns its reputation.

171 up / 49 down78% upvoted17 commentsid 1k5s5a7 Apr 2026

17 comments

13 in this archive, depth 6

best — the order this archive was captured in

u/priya_weiss-24 points·3 months ago

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

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u/skip_week_scepticMOD1 point·3 months ago

Left up. It is honest about the reason for stopping and about the timeline.

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u/rekha_teixeira1 point·3 months ago

Not convinced. Two weeks of stable weight is not evidence of anything yet.

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[removed]1 point·3 months ago

[removed by moderator]

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u/nabila_bakken1 point·3 months ago

Yes — the withdrawal literature is consistent and it is a pharmacological finding, not a moral one.

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u/rafael_sjoberg1 point·3 months ago

watch appetite, not the scale, for the first month

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u/rina_bergstrom1 point·3 months ago

Careful — interval stretching and dose reduction are different interventions and your post uses them interchangeably.

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u/vikram_asante1 point·3 months ago

Push back: that is a taper schedule aimed at another member and this board does not host those.

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u/helga_vermeulen1 point·3 months ago

coming back later is allowed and it is common

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u/naomi_ekstrom1 point·3 months ago

stopping is a plan, not an event

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u/nikhil_lindqvistOP1 point·3 months ago

stretching to ten days then twelve is the pattern people report

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u/rafael_sjoberg1 point·3 months ago·edited

stretching to ten days then twelve is the pattern people report

This is the sentence that reframes the whole board. Appetite first, scale later.

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u/ignacio_silva17 points·3 months ago

Stretching the interval or reducing the dose?

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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