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c/tapering·submitted 2 months ago by u/rafael_sjoberg

[Results] 9 weeks on 7.5mg, full numbers, ask me anything boring

Resultsbranch of 7 comments

9 weeks on 7.5mg, full numbers, ask me anything boring. Same spreadsheet I have been keeping since the start, nothing retrofitted. To save the first four comments: 9 weeks and 7.5mg. With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the…

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7 comments, started 2 months ago
u/ferran_krastev317 points·2 months ago

Appetite is the proximal effect and weight is the lagging integrated outcome, which is why watching appetite gives you an earlier and more honest signal.

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[removed]232 points·2 months ago

[removed by moderator]

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u/rafael_sjobergOP186 points·2 months ago

That is a pause rather than a stop, and the plans for the two are not the same.

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u/rafael_sjobergOP140 points·2 months ago·edited

Correcting myself upthread: appetite returned at week 12 for me, not the week I posted.

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u/ismael_eriksen67 points·2 months ago

coming back later is allowed and it is common

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u/camila_marchand243 points·2 months ago

Cosigning that cost and supply are legitimate reasons. Most of the stopping threads here are one of those two.

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u/rafael_sjobergOP174 points·2 months ago

Wrote down where I was before changing anything. That single page made the following six months interpretable.

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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