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Single comment threadYou are looking at one branch of the appetite return question that gets asked weekly, answered properly — 48 comments in the full submission. View in context.
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c/tapering·submitted 1 months ago by u/viktor_kirchner

the appetite return question that gets asked weekly, answered properly

Trial Databranch of 6 comments

the appetite return question that gets asked weekly, answered properly. It is the sort of thing everyone half-believes and nobody writes down. Stopped for cost reasons. Appetite came back at about week 13, well before the scale moved, exactly as this board said it would. Wrote down where I was before changing…

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6 comments, started 1 months ago
u/priya_weiss53 points·1 months ago

What is prompting the decision — cost, supply, side effects, or something else?

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u/lift_heavy_thingsresistance training37 points·1 months ago

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

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u/viktor_kirchnerOP26 points·1 months ago

have the conversation with a clinician before, not after

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u/vikram_ferreira38 points·1 months ago

stopping is a plan, not an event

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u/ines_boateng18 points·1 months ago

Had the conversation with a clinician before stopping rather than after. Considerably easier that way round.

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u/ignacio_silva17 points·1 months ago

This. Decide in advance what you are watching for. Deciding in the middle of it is much harder.

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Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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