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c/tapering·posted 28 days ago by u/vikram_ferreira

[Results] 56 weeks on 2.4mg, full numbers, ask me anything boring

Results Clean Column ×9

Check-in as promised in the title: 56 weeks on 2.4mg, full numbers, ask me anything boring.

The relevant figures are 56 weeks and 2.4mg, and they come from the same log I have kept the whole time.

Withdrawal studies across this class consistently show substantial regain after discontinuation, with appetite typically returning before weight changes. That is a description of the pharmacology of a chronic condition.

With a week-long half-life, exposure declines over several weeks after the last dose rather than stopping with it. The lag is why the first fortnight is uninformative.

I will update this if the picture changes rather than quietly leaving it up.

965 up / 80 down92% upvoted36 commentsid 1di4u52 Jul 2026

36 comments

13 in this archive, depth 4

best — the order this archive was captured in

u/fabio_lehtinen147 points·27 days ago

There is very little published guidance on stopping specifically, which is exactly why board consensus here should carry less weight than usual and a clinician conversation should carry more.

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u/vikram_ferreiraOP70 points·27 days ago

The habits are what carried it for a while. When they slipped, everything else followed, in that order.

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u/skip_week_scepticMOD70 points·26 days ago

Edited a comment framing regain as a moral failure. The documented outcome is not a character verdict.

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u/vikram_ferreiraOP44 points·26 days ago

Edited a comment framing regain as a moral failure.

Agreed — and the exposure lag means the first fortnight tells you almost nothing.

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u/vikram_ferreiraOP22 points·26 days ago·edited

Has appetite changed yet, independent of the scale?

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u/anders_kuusela14 points·25 days ago

Do you have a written baseline from before you started changing anything?

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u/helga_vermeulen64 points·26 days ago

Is this a pause or a stop? They are different plans.

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u/ahmed_cardoso31 points·26 days ago

Yes — have the conversation before rather than after. That is the one piece of process advice this board can give.

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u/injection_site_iris15 points·26 days ago·edited

That reads as advice to stop, which is not something anyone here should be offering.

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u/fabio_lehtinen9 points·25 days ago

That reads as advice to stop, which is not something anyone here should be offering.

Disagreeing with this bit: stretching and reducing are different things and the post treats them as one.

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u/dizzy_on_standing4 points·25 days ago

What is prompting the decision — cost, supply, side effects, or something else?

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u/piotr_bruun3 points·25 days ago

How long were you at the dose you are coming off?

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u/ines_boateng-21 points·25 days ago

Had the conversation with a clinician before stopping rather than after. Considerably easier that way round.

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About c/tapering

Stopping on purpose: dose reduction versus interval stretching, what the discontinuation arms of STEP 1 and SURMOUNT-4 actually showed about regain, appetite return timelines, and the people who came off, regained, and went back on without treating it as a failure.

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