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c/t2dglp1·submitted 10 months ago by u/stablecoin_steve

three years of metformin threads, summarised so you do not have to read them

Discussionbranch of 6 comments

The title is the argument: three years of metformin threads, summarised so you do not have to read them. Here is the rest of it. Variability dropped before the average did, which was visible on the sensor and invisible on the lab result. Assumed the weight endpoints from the obesity trials applied to my situation.…

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6 comments, started 10 months ago
u/teodor_duarte3 points·10 months ago

Incretin-based agents stimulate insulin secretion in a glucose-dependent manner, which is why hypoglycaemia risk with them alone is low. Risk rises with agents that act independently of glycaemia.

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u/tomas_lundgren1 point·10 months ago·edited

I would not compare your numbers to that population. Different baseline, different regimen, different trial.

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[deleted]1 point·10 months ago

[deleted]

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u/appeal_letter_al1 point·10 months ago

variability matters as much as the mean

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u/stablecoin_steveOP1 point·10 months ago

Time in range told me far more than the average did. Two quarters with the same A1c looked completely different on the sensor.

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u/baseline_drifteranalytical1 point·10 months ago

Incretin-based agents stimulate insulin secretion in a glucose-dependent manner, which is why hypoglycaemia risk with them alone is low.

Disagreeing with this line: that endpoint is from the obesity programme and does not answer the question.

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Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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