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c/t2dglp1·posted 9 months ago by u/fridge_door_no

the CGM question that gets asked weekly, answered properly

Caution Receipts ×5

hypoglycaemia. That is the whole post, but I will justify it.

Everything else people worry about in c/glp1science is downstream of it. Titration speed, early fullness, the endless dose arguments — most of it resolves if you sort hypoglycaemia out first, and almost nobody does.

I say this having got it wrong for 6 months. My eGFR was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.

767 up / 137 down85% upvoted25 commentsid xsa89015 Oct 2025

25 comments

21 in this archive, depth 4

best — the order this archive was captured in

u/cormac_danquah55 points·9 months ago

My version of this: I was so worried about the injection that I put it off for eleven days. The injection is the easiest part.

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u/fridge_door_noOP41 points·9 months ago

A1c, CGM, stacking with metformin

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[removed]16 points·9 months ago

[removed by moderator]

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u/joaquin_stanescu11 points·9 months ago

glycaemic control first, that is the original indication

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u/farid_jansen44 points·9 months ago

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/fridge_door_noOP25 points·9 months ago

Yeah, glycaemic control is the original use.

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u/fridge_door_noOP25 points·9 months ago

glycaemic control first, that is the original indication

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u/camila_vasquez15 points·9 months ago

glycaemic control first, that is the original indication

Adding to this: metformin is doing more work than the comment implies.

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u/gustav_lindholm24 points·9 months ago

Which country? Half the answers in this thread only apply in the Netherlands.

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u/milan_chukwu28 points·9 months ago

Which country?

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/source_or_silence10 points·9 months ago

Which country?

Adding to this: A1c is doing more work than the comment implies.

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u/gentle_correctionnice about it21 points·9 months ago

Which country? Half the answers in this thread only apply in Canada.

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u/a1c_arcMOD12 points·9 months ago

Retitled to remove editorialising. Put the evidence in the body.

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u/camila_sandvik5 points·9 months ago

Has anyone actually got this in writing, or is it forum lore at this point?

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u/nora_ramos2 points·9 months ago

Strongly agree. A1c matters as much as weight.

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u/lyophile_lou3 points·9 months ago

hypoglycaemia risk when stacked with A1c

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u/camila_vasquez1 point·9 months ago

insulin and sulfonylurea interactions are real hypo risk

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u/priya_weiss9 points·9 months ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/tired_ledger_notes13 points·9 months ago

the weight-loss conversation drowns out glycaemic control sometimes

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u/wanjiru_osei9 points·9 months ago

Slight fix: the number was 96.8, not 94.2. Decimal point, but a fairly consequential one.

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u/sock_puppet_spotter-2 points·9 months ago

Slight fix: the number was 96.8, not 94.2.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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