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c/t2dglp1·submitted 7 months ago by u/not_my_main_nm

[Results] 83 weeks, 13kg, and CGM was the hard part

Resultsbranch of 8 comments

Update, and the title has the headline: 83 weeks, 13kg, and CGM was the hard part. The numbers the title promised, since a headline without them is worthless: 83 weeks and 13kg. Everything below is context for those. Sensor accuracy varies across wear, and readings on the first day are the least reliable. Calibration…

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8 comments, started 7 months ago
u/adnan_karlsen492 points·7 months ago

Postprandial excursions typically respond earlier than fasting glucose, so the sequence people observe is not a sign that something is not working.

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u/gentle_correctionMOD255 points·7 months ago

Identifying details redacted from the exported report above.

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u/farid_jansen91 points·7 months ago

Assumed the weight endpoints from the obesity trials applied to my situation. They are different programmes.

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u/joaquin_trevino63 points·7 months ago

This. Hypoglycaemia risk in this class is driven mostly by the other agents in the regimen.

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u/not_my_main_nmOP275 points·7 months ago

Small fix — insulin secretion in this class is glucose-dependent, which is precisely why the risk you describe comes from the other agent.

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u/hamza_weiss217 points·7 months ago

nothing here replaces the person managing your diabetes

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u/kian_solberg82 points·7 months ago

Agreed on variability. Two people with the same average can have completely different days.

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u/cormac_danquah67 points·7 months ago·edited

Disagree — that is an obesity trial endpoint and this thread is about glycaemic control.

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Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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