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c/t2dglp1·submitted 1 year ago by u/not_my_main_nm

anyone else notice hypoglycaemia kicking in around week 8

Cautionbranch of 6 comments

Check-in as promised in the title: anyone else notice hypoglycaemia kicking in around week 8. On hypoglycaemia, because the risk gets attributed to the wrong thing constantly. Incretin-based agents stimulate insulin secretion in a glucose-dependent way: the effect scales with glycaemia rather than acting…

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6 comments, started 1 year ago
u/hugo_norgaard6 points·1 year ago

a single high reading is not a trend

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u/emil_okwuosa4 points·1 year ago

a single high reading is not a trend

hugo_norgaard is right that the fasting number moves last. Knowing that in advance saves months of worry.

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u/marisol_moreau1 point·1 year ago

A1c, CGM, or fingersticks — which are we discussing?

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u/nils_ferreira1 point·1 year ago

Variability dropped before the average did, which was visible on the sensor and invisible on the lab result.

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u/hassan_ostergaard1 point·1 year ago

dose for glycaemic control is not the same conversation as dose for weight

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u/nhs_waitlist_nUK1 point·1 year ago·edited

Correction: that trial is the diabetes programme and the figure you quoted is its glycaemic endpoint, not a weight result.

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Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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