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c/t2dglp1·submitted 1 months ago by u/nadia_norgaard

[PSA] hypoglycaemia is not what most of this community thinks it is

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Writing this once so it can be linked instead of retyped: hypoglycaemia is not what most of this community thinks it is. Assumed the weight endpoints from the obesity trials applied to my situation. They are different programmes. Variability dropped before the average did, which was visible on the sensor and…

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6 comments, started 1 months ago
u/sanne_laurent44 points·1 months ago·edited

Push back: one sensor reading is not a data point worth acting on, especially in the first day of wear.

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u/osman_ferrari0 points·1 months ago

Push back: one sensor reading is not a data point worth acting on, especially in the first day of wear.

Disagreeing with this line: that endpoint is from the obesity programme and does not answer the question.

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u/bianca_demir1 point·1 months ago

dose for glycaemic control is not the same conversation as dose for weight

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u/baseline_drifteranalytical18 points·1 months ago

The order things move in, since nobody explains it and it worries people.

Postprandial excursions generally respond earliest. Variability tends to narrow before the average does, which is visible on a sensor and invisible on a lab result. Fasting glucose is often the laggard, and A1c — being a three-month average — is the last thing to reflect anything.

So a month in which the sensor looks better and the fasting number has not moved is the ordinary sequence, not a contradiction. Knowing that in advance would have saved me a quarter of unnecessary worry, which is why it is worth writing down.

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u/fridge_door_no5 points·1 months ago

Small fix — insulin secretion in this class is glucose-dependent, which is precisely why the risk you describe comes from the other agent.

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u/kaia_cabrera4 points·1 months ago

That is a sensor value, not a plasma value, and the two are not interchangeable at that level of precision.

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Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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