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c/t2dglp1·posted 1 months ago by u/zaid_dahlberg

24 months in and metformin is still the thing I get wrong

Results Clean Column ×7 Well Actually ×3

Reporting in. 24 months in and metformin is still the thing I get wrong.

24 months. Those are measured, not estimated, and not rounded up in my favour.

My ApoB moved and it turned out to have nothing to do with glucose at all.

Incretin-based agents stimulate insulin secretion in a glucose-dependent manner, which is why hypoglycaemia risk with them alone is low. Risk rises with agents that act independently of glycaemia.

Happy to answer the boring questions. Those are usually the ones worth asking.

1,333 up / 181 down88% upvoted38 commentsid 1satzy9 Jun 2026

38 comments

15 in this archive, depth 3

best — the order this archive was captured in

u/joaquin_trevino299 points·1 months ago

Sensor accuracy varies across wear, and readings on the first day are the least reliable. Calibration practice and compression artefacts explain many alarming single values.

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u/a1c_arcMOD166 points·1 months ago

Identifying details redacted from the exported report above.

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u/wanjiru_osei205 points·1 months ago

variability matters as much as the mean

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u/arne_amankwah107 points·1 months ago

A1c reflects average glycaemia over roughly the preceding three months, weighted towards the most recent weeks. It cannot show variability and it lags any change you make.

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u/nils_ferreira38 points·1 months ago

Continuous monitoring shows the shape: postprandial excursions, overnight behaviour and time in range. Two people with identical A1c can have very different distributions.

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u/sock_puppet_spotter58 points·1 months ago

The three numbers, and what each one can and cannot tell you.

A1c is an average over about three months, weighted to the recent weeks. It cannot show variability and it lags change. Continuous monitoring shows the shape — excursions, overnight, time in range — and is where improvement usually becomes visible first. Fingersticks are point measurements, useful for sanity-checking a sensor and for specific questions.

Most of the frustrated posts here come from expecting one of the three to answer a question that belongs to another. And all three are inputs to a conversation with whoever manages your care, which is not this board.

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u/joaquin_stanescu24 points·1 months ago

What does time in range look like, not just the average?

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u/sock_puppet_spotter29 points·1 months ago

Correcting myself: 16 weeks between those two A1c results, which is too short an interval to interpret.

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u/arne_amankwah9 points·1 months ago

Kept fingersticks alongside the sensor for two weeks to sanity-check it. Worth doing once.

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u/hugo_norgaard0 points·1 months ago

Postprandial excursions typically respond earlier than fasting glucose, so the sequence people observe is not a sign that something is not working.

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u/kaia_cabrera0 points·1 months ago

CGM shows you the shape, A1c shows you the area

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u/throwaway_91821 point·1 months ago

sensor accuracy varies and the first day of a sensor is the worst

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u/zaid_dahlbergOP1 point·1 months ago

How long between the two A1c measurements?

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About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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