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c/t2dglp1·posted 13 days ago by u/joaquin_trevino

[Discussion] the weight conversation drowns out the glycaemic one

Discussion Receipts ×8

Right, the A1c question again, but with numbers this time.

I have 7 data points over 6 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 22, not week 71. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

449 up / 36 down93% upvoted27 commentsid 1rwn9l17 Jul 2026

27 comments

18 in this archive, depth 4

best — the order this archive was captured in

u/stubborn_batchlist_maybe68 points·12 days ago

CGM traces tell a story, numbers alone do not

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u/cormac_danquah51 points·12 days ago

Not convinced. The evidence does not support that reading.

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u/stablecoin_steve18 points·12 days ago

A1c, CGM, stacking with metformin

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u/yannick_barros67 points·11 days ago

This is correct. Hypo risk is real.

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u/teodor_duarte40 points·11 days ago

The injection-site soreness was genuinely awful for three weeks and then simply stopped. I know that is not useful information, but it is what happened.

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u/reship_roulette15 points·10 days ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/bianca_dziedzic8 points·10 days ago

You have restated the marketing copy. What is the actual substance here.

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[removed]3 points·10 days ago

[removed by moderator]

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u/ice_pack_auditcold chain40 points·12 days ago

Came off after 86 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.

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u/meal_prep_mira-37 points·11 days ago

glycaemic control first, that is the original indication

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u/cloudy_vial_carol26 points·12 days ago

Half-life is about 168 hours, so steady state lands around week 10–5. Practical consequence: what you feel in week 1 is not what that dose does.

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u/swirl_dont_shakereconstitution11 points·12 days ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/joaquin_trevinoOP8 points·12 days ago

Week 26 for me and the honest summary is: 44kg down, reflux manageable, and I have thought about food maybe four times today.

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u/joaquin_stanescu23 points·11 days ago

This is correct. Hypo risk is real.

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u/slow_logbook_notes3012 points·11 days ago

I am going to push back on this slightly.

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u/ilias_kaufmann9 points·10 days ago

hypoglycaemia risk when stacked with A1c

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u/tomas_lokken5 points·10 days ago·edited

the 7 A1c trend is the answer

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u/joaquin_trevinoOP6 points·11 days ago

Week 13 for me and the honest summary is: 36kg down, the food-noise thing manageable, and I have thought about food maybe four times today.

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About c/t2dglp1

Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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