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c/survodutide·submitted 1 months ago by u/cato_batista

is it normal to get constipation at week 7

Trial Databranch of 6 comments

is it normal to get constipation at week 7, logged the same way every week so the comparison is at least internally fair. Assumed the weight numbers were the point and was corrected. They are secondary to what this is being developed for. Independent purity results for this compound are very sparse across the whole…

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6 comments, started 1 months ago
u/sofia_danquah36 points·1 months ago

Imaging-derived liver fat fraction is a surrogate. It correlates with histology imperfectly, and a trial reporting one is not reporting the other.

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u/britt_okwuosa17 points·1 months ago·edited

Yes — histological endpoints are a far harder bar than the surrogate measures people are used to quoting.

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u/cato_batistaOP0 points·1 months ago

That figure is from the obesity programme, and this thread is about the hepatic one.

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u/samir_falk1 point·1 months ago

Biopsy-confirmed population or imaging-selected?

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u/endotoxin_elliemicro1 point·1 months ago·edited

Small fix — dual agonist, GLP-1 and glucagon. No GIP arm in this molecule.

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u/liv_vukovic12 points·1 months ago

Agreed that the endpoint definitions matter enormously and almost nobody reads them before quoting a response rate.

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