[Results] 28 weeks, 11kg, and MASH was the hard part
28 weeks, 11kg, and MASH was the hard part. Same spreadsheet I have been keeping since the start, nothing retrofitted.
Since the title puts numbers in the shop window: 28 weeks and 11kg.
Asked here what the difference was between the imaging and biopsy endpoints and got a genuinely excellent answer.
Looked for independent results across this whole site and found almost none. Worth knowing before forming an opinion.
Happy to answer the boring questions. Those are usually the ones worth asking.
best — the order this archive was captured in
Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use.
[removed by moderator]
phase 2 in liver disease is a different evidence question from weight
fibrosis improvement without worsening steatohepatitis is the phrase to learn
Agreed that the endpoint definitions matter enormously and almost nobody reads them before quoting a response rate.
dual GLP-1 and glucagon agonist, and the glucagon arm is the story
Imaging-derived liver fat fraction is a surrogate. It correlates with histology imperfectly, and a trial reporting one is not reporting the other.
Disagree — that is a weight endpoint from a different programme and you are quoting it in a hepatic context.
Is that a weight number from a different programme?
Yes — nothing containing this is approved anywhere, which is the first fact and usually the last one mentioned.
This. Biopsy-confirmed and imaging-suggested are different evidentiary categories and get run together constantly.
Retitled to name the endpoint. Histological and imaging results are not interchangeable and the original title implied they were.
Retitled to name the endpoint.
This is the framing the board needs. It is a hepatic programme first.
That is an escalation schedule for an unapproved compound and this board does not host those.
- 1Nothing containing this compound is approved anywhere. Research-use-only…6 comments in this branch · started by u/nora_ramos