three years of MASH threads, summarised so you do not have to read them
Thinking out loud about this: three years of MASH threads, summarised so you do not have to read them. Spent an evening on the histology scoring system and understood the trial literature far better afterwards. Looked for independent results across this whole site and found almost none. Worth knowing before forming…
do not import intuitions from the obesity programmes
Left up. It reads the paper carefully and is explicit about the population.
Right, and the trial titration was slow for reasons that are visible in the tolerability tables.
Small fix — dual agonist, GLP-1 and glucagon. No GIP arm in this molecule.
do not import intuitions from the obesity programmes
Adding the standing caveat — unapproved compound, research material is not for human use.
biopsy-confirmed is not the same as imaging-suggested
dual GLP-1 and glucagon agonist, and the glucagon arm is the story