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c/survodutide·submitted 1 year ago by u/trialwatch_theo

glucagon is the most under-discussed thing on this board

Cautionbranch of 7 comments

Something I keep coming back to: glucagon is the most under-discussed thing on this board. Imaging-derived liver fat fraction is a surrogate. It correlates with histology imperfectly, and a trial reporting one is not reporting the other. Nothing containing this compound is approved anywhere. Research-use-only…

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7 comments, started 1 year ago
u/vitamin_d_void-12 points·1 year ago

Yes — nothing containing this is approved anywhere, which is the first fact and usually the last one mentioned.

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u/trialwatch_theoOPtrial nerd1 point·1 year ago

Biopsy-confirmed population or imaging-selected?

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u/trialwatch_theoOPtrial nerd1 point·1 year ago

Which phase and which arm are you quoting?

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u/britt_okwuosa1 point·1 year ago

fibrosis improvement without worsening steatohepatitis is the phrase to learn

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u/whois_wanda1 point·1 year ago

Histological endpoints in this field are scored on biopsy: resolution of steatohepatitis without worsening of fibrosis, or improvement in fibrosis without worsening of steatohepatitis. Both are harder to achieve and to interpret than an imaging surrogate.

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u/meera_sandvik1 point·1 year ago·edited

Small fix — dual agonist, GLP-1 and glucagon. No GIP arm in this molecule.

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u/laila_yilmaz1 point·1 year ago

biopsy-confirmed is not the same as imaging-suggested

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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