[Lab] 24th independent test on QSC — 98.4% on a claimed 98.0%, and the trend is the interesting part
Short version of the title, which is already short: 24th independent test on QSC — 98.4% on a claimed 98.0%, and the trend is the interesting part. Longer version underneath. Since the title puts numbers in the shop window: 98.4% and 98.0%. The honest evidence position, written out so this board does not drift. Phase…
fibrosis improvement without worsening steatohepatitis is the phrase to learn
Imaging-derived liver fat fraction is a surrogate. It correlates with histology imperfectly, and a trial reporting one is not reporting the other.
the weight numbers are secondary to what this is being developed for
Went slowly because everything published describes a deliberate escalation. That is the extent of what I will say about it.
research material is not approved for human use, which is why the clinical record here is thin
phase 2 in liver disease is a different evidence question from weight
the hepatic data is what makes this compound different from the others
phase 2 in liver disease is a different evidence question from weight
This is the framing the board needs. It is a hepatic programme first.
this board is small because the compound is early
This. Biopsy-confirmed and imaging-suggested are different evidentiary categories and get run together constantly.
Asked here what the difference was between the imaging and biopsy endpoints and got a genuinely excellent answer.
Histological endpoints in this field are scored on biopsy: resolution of steatohepatitis without worsening of fibrosis, or improvement in fibrosis without worsening of steatohepatitis. Both are harder to achieve and to interpret than an imaging surrogate.
fibrosis improvement without worsening steatohepatitis is the phrase to learn
lina_ndiaye is right that biopsy and imaging endpoints are not interchangeable.
biopsy-confirmed is not the same as imaging-suggested
glucagon agonism and energy expenditure is the mechanistic thread
glucagon agonism and energy expenditure is the mechanistic thread
Disagreeing with this bit: that number comes from a different programme with a different population.