reading MASH threads from 2024 and half of it aged badly
reading MASH threads from 2024 and half of it aged badly. It is the sort of thing everyone half-believes and nobody writes down. Histological endpoints in this field are scored on biopsy: resolution of steatohepatitis without worsening of fibrosis, or improvement in fibrosis without worsening of steatohepatitis. Both…
Push back: the evidence here is phase 2, in a specific population, and it does not support a general ranking.
Retitled to name the endpoint. Histological and imaging results are not interchangeable and the original title implied they were.
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independent testing on this compound is very thin
Correction: that is the imaging endpoint, not the histological one. The paper reports both and they differ substantially.
glucagon agonism and energy expenditure is the mechanistic thread
That figure is from the obesity programme, and this thread is about the hepatic one.
That figure is from the obesity programme, and this thread is about the hepatic one.
Agreed — and the endpoint definitions are where the actual claim lives.