what changed for me between month 5 and month 8
what changed for me between month 5 and month 8. I am not trying to be the "source?" guy. I would just like a source. Assumed the weight numbers were the point and was corrected. They are secondary to what this is being developed for. Went slowly because everything published describes a deliberate escalation. That is…
MASH endpoints are histological, which is a much harder bar
Removed the escalation schedule. Unapproved compound, no protocols for other members, no exceptions.
Looked for independent results across this whole site and found almost none. Worth knowing before forming an opinion.
the hepatic data is what makes this compound different from the others
[removed by moderator]
Imaging-derived liver fat fraction is a surrogate. It correlates with histology imperfectly, and a trial reporting one is not reporting the other.
Is that a weight number from a different programme?
fibrosis improvement without worsening steatohepatitis is the phrase to learn
Not convinced. Imaging-based fat fraction is not the same as a histological response and the paper is explicit about that.