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c/survodutide·submitted 2 years ago by u/julia_mensa

why does nobody talk about MASH

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why does nobody talk about MASH, and I want the answer with the reasoning attached rather than just the conclusion. What this compound is actually being developed for, since the boards treat it as a weight-loss molecule with a footnote. It is a dual GLP-1 and glucagon receptor agonist, and the glucagon arm links to…

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12 comments, started 2 years ago
u/rania_marchand158 points·2 years ago

Independent purity results for this compound are very sparse across the whole site, which means any impression about consistency is built on almost nothing.

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u/whois_wanda130 points·2 years ago

Independent purity results for this compound are very sparse across the whole site, which means any impression about consistency is built on almost no

Disagreeing with this bit: that number comes from a different programme with a different population.

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u/annika_fonseca50 points·2 years ago

Yes — nothing containing this is approved anywhere, which is the first fact and usually the last one mentioned.

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u/teodor_szabo24 points·2 years ago

Biopsy-confirmed population or imaging-selected?

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u/cato_batista7 points·2 years ago

the titration in the trials was slow and deliberate

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u/kaia_cabrera6 points·2 years ago

How fast was the escalation in that protocol?

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u/teodor_szabo37 points·2 years ago

Has anyone posted an independent purity result for this compound?

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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