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Single comment threadYou are looking at one branch of [Paper] survodutide MASH data is the most interesting hepatic readout in the class — 15 comments in the full submission. View in context.
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c/survodutide·submitted 3 days ago by u/kasper_cabrera

[Paper] survodutide MASH data is the most interesting hepatic readout in the class

Paperbranch of 9 comments

survodutide MASH data is the most interesting hepatic readout in the class. Change my mind, genuinely — I have no stake in being right about this. Nothing containing this compound is approved anywhere. Research-use-only material is not approved for human use. Imaging-derived liver fat fraction is a surrogate. It…

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9 comments, started 2 days ago
u/draw_up_dizzy15 points·2 days ago

glucagon agonism and energy expenditure is the mechanistic thread

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u/cold_chromatogram_only10 points·1 days ago

Small fix — dual agonist, GLP-1 and glucagon. No GIP arm in this molecule.

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u/crosspost_bot_no12 points·1 days ago

glucagon agonism and energy expenditure is the mechanistic thread

draw_up_dizzy is right that biopsy and imaging endpoints are not interchangeable.

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[removed]11 points·1 days ago

[removed by moderator]

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u/cormac_danquah16 points·1 days ago

Which phase and which arm are you quoting?

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u/renzo_yildiz5 points·1 days ago

Correction: that is the imaging endpoint, not the histological one. The paper reports both and they differ substantially.

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u/britt_abubakar4 points·1 days ago

This. Biopsy-confirmed and imaging-suggested are different evidentiary categories and get run together constantly.

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u/kasper_cabreraOP2 points·16 hr ago

Has anyone posted an independent purity result for this compound?

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u/andres_dahlberg1 point·6 hr ago

fibrosis improvement without worsening steatohepatitis is the phrase to learn

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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