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c/survodutide·posted 14 days ago by u/cato_girard

[Caution] hepatic endpoints need biopsy data, not an ALT screenshot

Caution Sourced ×6

Confession thread, sort of.

I went from 1.0mg to 15mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 17 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have muscle cramps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 17 reads it before doing the same thing.

311 up / 45 down87% upvoted25 commentsid 19q60116 Jul 2026

25 comments

16 in this archive, depth 4

best — the order this archive was captured in

u/refund_ledger44 points·12 days ago

Strongly agree. The safety story is separate.

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u/incretin_ivypharmacology37 points·12 days ago

Phase 23 or 35?

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[deleted]17 points·12 days ago

[deleted]

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u/joaquin_ivaturi13 points·12 days ago

the safety profile is not just tirzepatide amplified

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u/cato_girardOP6 points·11 days ago

The thing nobody prepared me for was the quiet. Not the appetite, the quiet. The constant negotiation in my head about food just stopped.

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u/cato_girardOP10 points·11 days ago

This is correct. Do not generalise from tirzepatide.

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u/renzo_yildiz16 points·12 days ago

rodent dual agonist is investigation only

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u/rania_marchand18 points·13 days ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/incretin_ivyMOD8 points·12 days ago

Flair changed to match the content. Read the sidebar before posting next time and we are square.

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u/cato_batista5 points·12 days ago

the safety profile is not just tirzepatide amplified

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u/kaia_cabrera2 points·12 days ago

MASH claims need the trial and the biopsy endpoint

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u/border_paperwork3 points·12 days ago

the safety profile is not just tirzepatide amplified

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/cato_girard12 points·12 days ago

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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Survodutide-specific discussion: glucagon-receptor co-agonism, the hepatic fat and MASH resolution data, and how the side-effect profile compares with GIP-based dual agonism. Small community, high signal.

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