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Single comment threadYou are looking at one branch of genuine question about reflux that I am slightly embarrassed to ask — 42 comments in the full submission. View in context.
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c/sideeffects·submitted 2 years ago by u/sequence_checker

genuine question about reflux that I am slightly embarrassed to ask

Resolvedbranch of 11 comments

genuine question about reflux that I am slightly embarrassed to ask. I am not trying to be the "source?" guy. I would just like a source. The pattern almost everyone here describes, written out once so it can be linked. A step up is followed by a rough window — commonly constipation arriving the day after the shot…

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11 comments, started 2 years ago
u/mikkel_kimani349 points·2 years ago

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

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u/sequence_checkerOPresearch peptides410 points·2 years ago

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

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u/mass_spec_maggieMS340 points·2 years ago

Agreed. Slowing down at meals did more for my reflux than everything I bought to fix it, which was embarrassing to discover.

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u/sequence_checkerOPresearch peptides216 points·2 years ago·edited

How long has it been going on for now?

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[removed]157 points·2 years ago

[removed by moderator]

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u/sequence_checkerOPresearch peptides212 points·2 years ago

Held the dose for an extra six weeks instead of stepping. The injection-site soreness settled and I lost the same amount anyway.

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u/zeynep_zielinski154 points·2 years ago

early fullness for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

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u/line_petrov189 points·2 years ago

holding a dose an extra month is a legitimate answer to bad tolerance

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u/signe_villalobos115 points·2 years ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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u/chidi_demir57 points·2 years ago

Same pattern here. It settled at a stable dose without me doing anything clever.

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u/ferran_dahlberg38 points·2 years ago·edited

Constipation is mostly reduced intake plus reduced fluid, not a direct effect.

Agreed, with the caveat that "usually settles" is not "always settles" and the exceptions should still get asked about properly.

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