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c/sideeffects·posted 1 year ago by u/step_therapy_s

genuine question about nausea that I am slightly embarrassed to ask

Resolved Clean Column ×5 Sourced ×1

genuine question about nausea that I am slightly embarrassed to ask, and I want the answer with the reasoning attached rather than just the conclusion.

Bought four different things to fix my nausea. What actually worked was eating half as fast.

food noise for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

Held the dose for an extra six weeks instead of stepping. The sulphur burps settled and I lost the same amount anyway.

Corrections welcome, especially the pedantic ones. Pedantry is how this board earns its reputation.

2,889 up / 839 down77% upvoted51 commentsid nzmg9k27 Aug 2024

51 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/sofia_wikstrom275 points·1 year ago

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

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u/saskia_lokken218 points·1 year ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 81 probably does not, and that is worth saying to a clinician rather than to us.

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u/laila_delgado175 points·1 year ago

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/rania_diallo53 points·1 year ago

I would be careful here. "Everyone gets this" is not true, and it makes the people who get something unusual assume they are fine when they should be asking.

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u/rekha_mbeki15 points·1 year ago

Not convinced by that mechanism. Slowed gastric emptying explains fullness and reflux; it does not explain what you are describing.

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u/amara_haddad229 points·1 year ago

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal.

sofia_wikstrom is right about the timing. The day-of-week pattern is the diagnostic bit, not the severity.

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[removed]103 points·1 year ago

[removed by moderator]

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u/vendorinvestigate_vic-29 points·1 year ago

Keeping a log, and what to put in it.

One line a day: dose, day since injection, what the symptom was and how bad out of five, and roughly what you ate. Two months of that fits on one page and the pattern is obvious on paper in a way it never is in your head.

Mine showed a clean day-two-to-day-four window I had been describing as "random". Once you can see the pattern you can plan around it, and planning around it is most of the relief.

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u/step_therapy_s145 points·1 year ago

Reflux was the one that got me. Stopped eating in the three hours before bed and it went from nightly to almost never.

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u/cesar_oyelaran119 points·1 year ago

That reads like advice, and none of us can give it. Describe what you did, not what somebody else should do.

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u/idris_iyer58 points·1 year ago

Careful with the supplement recommendation. There is no evidence for it here and the mechanism you are proposing does not hold.

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u/step_therapy_sOP24 points·1 year ago

Are you eating in the couple of hours before you sleep?

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u/rania_marchand42 points·1 year ago

the first fortnight after a step is the worst of it, then it settles

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u/step_therapy_sOP33 points·1 year ago

eating slower does more than most of the supplements people recommend

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u/step_therapy_sOP25 points·1 year ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/clara_weiss9 points·1 year ago

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

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u/lina_dziedzic32 points·1 year ago

How long has it been going on for now?

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u/zaid_balogun70 points·1 year ago

Kept a one-line-a-day log for two months. The pattern was obvious on paper and invisible in my head.

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u/fabio_nkemelu35 points·1 year ago·edited

Kept a one-line-a-day log for two months.

This is the shape almost everybody here describes, and it is the single most reassuring thing in the thread.

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u/rafael_ostergaard27 points·1 year ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

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u/peptidemeter_pat14 points·1 year ago·edited

Correction: that is a known effect of reduced intake rather than a direct drug effect. The distinction matters because the fix is different.

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u/line_petrov27 points·1 year ago

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

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u/wrong_network_w52 points·1 year ago

On buying things to fix side effects, which I did extensively and would not do again.

The interventions that changed anything for me were all behavioural and free: smaller meals, eating slower, stopping food a few hours before sleep, more fibre and considerably more water. The things I bought did nothing I could detect, and I was motivated to detect something.

The other lever, which people forget, is time at dose. Holding rather than stepping is a legitimate plan and it fixed my tolerance where nothing else did.

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u/hassan_ostergaard42 points·1 year ago

Disagree. Severe abdominal pain is not on the list of things to wait out, and this board should not be treating it as one.

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u/laila_delgado101 points·1 year ago

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

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u/blunt_coldbox_202470 points·1 year ago

write down when it starts and stops, the pattern is the useful part

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u/naomi_erdogan56 points·1 year ago

Pushback: you changed the dose, the meal timing and the training in the same fortnight, so the attribution is guesswork.

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u/yannick_barros37 points·1 year ago·edited

How long after a step up did this start?

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u/enzo_danquah23 points·1 year ago

Has anything else changed in the same window?

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u/insulin_syringe_ian26 points·1 year ago

Agreed. Slowing down at meals did more for my nausea than everything I bought to fix it, which was embarrassing to discover.

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Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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