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c/sideeffects·posted 2 years ago by u/emil_barros

how much of what we believe about hair loss actually comes from gallbladder threads

Resolved Cold Box ×3 Sourced ×1

how much of what we believe about hair loss actually comes from gallbladder threads, and I want the answer with the reasoning attached rather than just the conclusion.

The pattern almost everyone here describes, written out once so it can be linked.

A step up is followed by a rough window — commonly food noise arriving the day after the shot and easing by day four, worst in the first fortnight, then flattening out. At a stable dose it usually settles further. Constipation and fatigue tend to track intake and fluid rather than the compound directly, which is why the unglamorous answers work.

What sits outside that pattern: severe pain, symptoms that appear from nowhere weeks into a stable dose, or anything getting worse rather than better over a month. None of that is a board question and none of us can answer it for you.

Held the dose for an extra six weeks instead of stepping. The fatigue settled and I lost the same amount anyway.

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

Sceptical readings welcome. The confident ones are the ones I distrust.

3,004 up / 917 down77% upvoted49 commentsid kxno4w3 Feb 2024

49 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/elin_trevino-7 points·2 years ago

A symptom that begins the day after the shot and fades by day four tracks the exposure curve. One that appears at random in week 52 probably does not, and that is worth saying to a clinician rather than to us.

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u/enzo_danquah1 point·2 years ago

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

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u/zeynep_zielinski1 point·2 years ago

That reads like advice, and none of us can give it. Describe what you did, not what somebody else should do.

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u/signe_villalobos1 point·2 years ago

write down when it starts and stops, the pattern is the useful part

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u/quiet_moderatorMOD1 point·2 years ago

Left up. It is a description of one person’s week and it is flagged as such.

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u/emil_barrosOP1 point·2 years ago

What is intake actually looking like — fibre and water especially?

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u/mikkel_kimani1 point·2 years ago

Cosigning the fibre and water answer. Unglamorous, free, and it fixed it for me inside a week.

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u/vendorinvestigate_vic1 point·2 years ago

Careful with the supplement recommendation. There is no evidence for it here and the mechanism you are proposing does not hold.

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[deleted]1 point·2 years ago

[deleted]

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u/ilias_cabrera219 points·2 years ago

Agreed. Slowing down at meals did more for my reflux than everything I bought to fix it, which was embarrassing to discover.

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u/food_noise_gonemaintenance129 points·2 years ago·edited

Nobody warned me about early fullness and I would have liked the warning. It was not dangerous, it was just deeply unpleasant and completely unexpected.

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u/enzo_danquah168 points·2 years ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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u/neha_rahimi133 points·2 years ago

Pushback: you changed the dose, the meal timing and the training in the same fortnight, so the attribution is guesswork.

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u/sena_teixeira74 points·2 years ago

a rough fortnight at each step is normal, a rough three months is not

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u/emil_barrosOP58 points·2 years ago

fatigue plus low intake is usually just low intake

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u/emil_barrosOP44 points·2 years ago

Correction: that is a known effect of reduced intake rather than a direct drug effect. The distinction matters because the fix is different.

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u/lina_dziedzic47 points·2 years ago

I would be careful here. "Everyone gets this" is not true, and it makes the people who get something unusual assume they are fine when they should be asking.

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u/vendorinvestigate_vic190 points·2 years ago

Right, and the hair thing is worth repeating: it tracks the rate of loss rather than the compound, and it stops.

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u/quiet_moderatormod110 points·2 years ago

Disagree. Severe abdominal pain is not on the list of things to wait out, and this board should not be treating it as one.

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u/rania_diallo89 points·2 years ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/zaid_balogun28 points·2 years ago

the muscle cramps that arrives at week 12 out of nowhere is usually something else

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u/signe_villalobos22 points·2 years ago

Not convinced by that mechanism. Slowed gastric emptying explains fullness and reflux; it does not explain what you are describing.

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u/long_post_larry10 points·2 years ago

holding a dose an extra month is a legitimate answer to bad tolerance

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u/neha_rahimi16 points·2 years ago

the muscle cramps that arrives at week 12 out of nowhere is usually something else

Agreed, with the caveat that "usually settles" is not "always settles" and the exceptions should still get asked about properly.

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u/placebo_arm_pam9 points·2 years ago

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/mikkel_kimani129 points·2 years ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

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u/amara_haddad78 points·2 years ago

Is it every week or did it start at a particular dose?

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u/aurel_mwangi0 points·2 years ago

Has anything else changed in the same window?

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u/reta_and_regret1 point·2 years ago

Same pattern here. It settled at a stable dose without me doing anything clever.

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u/ferran_dahlberg1 point·2 years ago

the food noise going quiet is the effect people came for, and reflux is the toll for the first fortnight

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Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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