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c/sideeffects·posted 1 year ago by u/liv_vukovic

three years of reflux threads, summarised so you do not have to read them

PSA Clean Column ×9 Sourced ×2 Slow Clap ×1

three years of reflux threads, summarised so you do not have to read them. It is the sort of thing everyone half-believes and nobody writes down.

reflux for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

Bought four different things to fix my constipation. What actually worked was eating half as fast.

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

That is everything I have. The rest is opinion and I have tried to keep it out.

6,717 up / 1,332 down83% upvoted32 commentsid gtd5ga20 May 2025

32 comments

23 in this archive, depth 4

best — the order this archive was captured in

u/coring_the_stopper552 points·1 year ago

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

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u/nausea_notesMOD290 points·1 year ago

This one needs a clinician rather than a comment section, and we have said so in the thread rather than removing it.

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u/chidi_demir243 points·1 year ago·edited

Correction: that is a known effect of reduced intake rather than a direct drug effect. The distinction matters because the fix is different.

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u/placebo_arm_pam430 points·1 year ago

Yes — the day-two-to-day-four window is so consistent across this board that it is almost diagnostic.

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u/rania_diallo364 points·1 year ago·edited

Mine settled at week 16 and has not come back since, across two more steps.

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[removed]260 points·1 year ago

[removed by moderator]

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u/rania_diallo136 points·1 year ago

smaller meals, earlier, is the boring advice that works

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u/liv_vukovicOP98 points·1 year ago

Correcting my own comment above: I said day three and my log says day two. Same pattern, wrong day.

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u/liv_vukovicOP140 points·1 year ago

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/piotr_bruun71 points·1 year ago·edited

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/naomi_erdogan41 points·1 year ago

fibre and water before you buy anything to fix it

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u/diego_sorensen218 points·1 year ago

Held the dose for an extra six weeks instead of stepping. The sulphur burps settled and I lost the same amount anyway.

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u/vendorinvestigate_vic155 points·1 year ago

nobody warns you about how much of this is timing rather than dose

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u/liv_vukovicOP61 points·1 year ago

if it is severe or persistent that is a clinician question, not a board question

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u/britt_abubakar29 points·1 year ago

the first fortnight after a step is the worst of it, then it settles

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u/tomas_broberg55 points·1 year ago

fatigue plus low intake is usually just low intake

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u/liv_vukovic37 points·1 year ago

hair shedding follows the weight loss, not the drug, and it stops

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u/sofia_wikstrom183 points·1 year ago

Reflux was the one that got me. Stopped eating in the three hours before bed and it went from nightly to almost never.

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u/ferritin_low175 points·1 year ago

On buying things to fix side effects, which I did extensively and would not do again.

The interventions that changed anything for me were all behavioural and free: smaller meals, eating slower, stopping food a few hours before sleep, more fibre and considerably more water. The things I bought did nothing I could detect, and I was motivated to detect something.

The other lever, which people forget, is time at dose. Holding rather than stepping is a legitimate plan and it fixed my tolerance where nothing else did.

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u/kavya_kravchenko-16 points·1 year ago

sulphur burps are unpleasant and they are not dangerous

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u/quiet_moderatormod-23 points·1 year ago

the food noise that arrives at week 28 out of nowhere is usually something else

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u/rina_bergstrom1 point·1 year ago

Severe, or unpleasant? They are genuinely different questions and the answers diverge.

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u/hassan_ostergaard1 point·1 year ago

That reads like advice, and none of us can give it. Describe what you did, not what somebody else should do.

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Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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