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c/sideeffects·posted 9 months ago by u/rina_bergstrom

switched from 0.5mg to 1.7mg and injection-site soreness got better, not worse

Resolved Cold Box ×3 Well Actually ×1 Long Haul ×2

switched from 0.5mg to 1.7mg and injection-site soreness got better, not worse. I have gone back and forth on this for months.

Hard numbers: 0.5mg and 1.7mg. Anything softer than that is flagged as an impression.

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

food noise for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

Happy to answer the boring questions. Those are usually the ones worth asking.

5,358 up / 335 down94% upvoted33 commentsid ekv7aw16 Oct 2025

33 comments

30 in this archive, depth 6

best — the order this archive was captured in

u/baseline_drifteranalytical802 points·9 months ago

Keeping a log, and what to put in it.

One line a day: dose, day since injection, what the symptom was and how bad out of five, and roughly what you ate. Two months of that fits on one page and the pattern is obvious on paper in a way it never is in your head.

Mine showed a clean day-two-to-day-four window I had been describing as "random". Once you can see the pattern you can plan around it, and planning around it is most of the relief.

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u/wrong_network_w184 points·9 months ago·edited

fibre and water before you buy anything to fix it

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u/sequence_checkerresearch peptides746 points·9 months ago

Held the dose for an extra six weeks instead of stepping. The food noise settled and I lost the same amount anyway.

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u/aa_analysis_andy597 points·9 months ago·edited

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

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u/rina_bergstromOP428 points·9 months ago

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/clara_weiss0 points·9 months ago

Correction: that is a known effect of reduced intake rather than a direct drug effect. The distinction matters because the fix is different.

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u/ayesha_radich1 point·9 months ago

Correction: that is a known effect of reduced intake rather than a direct drug effect.

clara_weiss is right about the timing. The day-of-week pattern is the diagnostic bit, not the severity.

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u/gentle_correctionnice about it1 point·9 months ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/piotr_bruun411 points·9 months ago

smaller meals, earlier, is the boring advice that works

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u/ferran_dahlberg137 points·9 months ago

smaller meals, earlier, is the boring advice that works

Adding to this — holding the dose rather than stepping is the option people forget they have.

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u/iman_castellanos44 points·9 months ago

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

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u/iman_falk11 points·9 months ago

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss.

This is the shape almost everybody here describes, and it is the single most reassuring thing in the thread.

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u/rina_bergstromOP31 points·9 months ago

Correcting my own comment above: I said day three and my log says day two. Same pattern, wrong day.

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u/chidi_demir-4 points·9 months ago

the food noise going quiet is the effect people came for, and sulphur burps are the toll for the first fortnight

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u/tomas_broberg1 point·9 months ago

Has anything else changed in the same window?

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u/milan_villalobos1 point·9 months ago

nobody warns you about how much of this is timing rather than dose

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u/nabila_ogunleye249 points·9 months ago

Agreed. Slowing down at meals did more for my constipation than everything I bought to fix it, which was embarrassing to discover.

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u/quiet_moderatorMOD186 points·9 months ago

This one needs a clinician rather than a comment section, and we have said so in the thread rather than removing it.

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u/saskia_lokken102 points·9 months ago

Yes. Holding the dose is a real option and it does not mean you have failed at anything.

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u/naomi_erdogan135 points·9 months ago

Disagree. Severe abdominal pain is not on the list of things to wait out, and this board should not be treating it as one.

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u/priya_weiss46 points·9 months ago

write down when it starts and stops, the pattern is the useful part

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u/chidi_abubakar202 points·9 months ago

a rough fortnight at each step is normal, a rough three months is not

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u/neha_rahimi154 points·9 months ago

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

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u/bastian_eriksen179 points·9 months ago

Nobody warned me about constipation and I would have liked the warning. It was not dangerous, it was just deeply unpleasant and completely unexpected.

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u/iman_castellanos143 points·9 months ago

the reflux that arrives at week 22 out of nowhere is usually something else

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u/tomas_broberg64 points·9 months ago

Right, and the hair thing is worth repeating: it tracks the rate of loss rather than the compound, and it stops.

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u/rania_marchand16 points·9 months ago

reflux at night, try not eating in the three hours before bed

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u/cormac_danquah4 points·9 months ago

if it is severe or persistent that is a clinician question, not a board question

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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