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c/sideeffects·posted 2 years ago by u/saskia_lokken

nobody warned me about fatigue and I would have liked the warning

PSA Receipts ×6 Cold Box ×1 Slow Clap ×2

nobody warned me about fatigue and I would have liked the warning. I have gone back and forth on this for months.

The pattern almost everyone here describes, written out once so it can be linked.

A step up is followed by a rough window — commonly food noise arriving the day after the shot and easing by day four, worst in the first fortnight, then flattening out. At a stable dose it usually settles further. Constipation and fatigue tend to track intake and fluid rather than the compound directly, which is why the unglamorous answers work.

What sits outside that pattern: severe pain, symptoms that appear from nowhere weeks into a stable dose, or anything getting worse rather than better over a month. None of that is a board question and none of us can answer it for you.

Held the dose for an extra six weeks instead of stepping. The fatigue settled and I lost the same amount anyway.

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

That is everything I have. The rest is opinion and I have tried to keep it out.

6,557 up / 706 down90% upvoted66 commentsid 1kqhv430 Aug 2023

66 comments

30 in this archive, depth 6

best — the order this archive was captured in

u/graph_it_gary532 points·2 years ago

Keeping a log, and what to put in it.

One line a day: dose, day since injection, what the symptom was and how bad out of five, and roughly what you ate. Two months of that fits on one page and the pattern is obvious on paper in a way it never is in your head.

Mine showed a clean day-two-to-day-four window I had been describing as "random". Once you can see the pattern you can plan around it, and planning around it is most of the relief.

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u/constipation_clubMOD289 points·2 years ago

Left up. It is a description of one person’s week and it is flagged as such.

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u/saskia_lokkenOP169 points·2 years ago·edited

Left up.

Agreed, with the caveat that "usually settles" is not "always settles" and the exceptions should still get asked about properly.

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u/rekha_mbeki596 points·2 years ago

write down when it starts and stops, the pattern is the useful part

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u/peptidemeter_pat-6 points·2 years ago

nobody warns you about how much of this is timing rather than dose

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u/sequence_checkerresearch peptides1 point·2 years ago·edited

nobody warns you about how much of this is timing rather than dose

peptidemeter_pat is right about the timing. The day-of-week pattern is the diagnostic bit, not the severity.

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u/slow_logbook_ftw181 points·2 years ago

Cosigning the fibre and water answer. Unglamorous, free, and it fixed it for me inside a week.

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u/sanne_laurent124 points·2 years ago

Correction: that is a known effect of reduced intake rather than a direct drug effect. The distinction matters because the fix is different.

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u/saskia_lokkenOP74 points·2 years ago

the food noise going quiet is the effect people came for, and reflux is the toll for the first fortnight

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[deleted]33 points·2 years ago

[deleted]

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u/liv_vukovic262 points·2 years ago

Mine settled at week 55 and has not come back since, across two more steps.

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u/mass_spec_maggieMS147 points·2 years ago

hair shedding follows the weight loss, not the drug, and it stops

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u/ayesha_erdogan405 points·2 years ago·edited

Pushback: you changed the dose, the meal timing and the training in the same fortnight, so the attribution is guesswork.

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u/bastian_eriksen96 points·2 years ago

if it is severe or persistent that is a clinician question, not a board question

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u/amara_haddad48 points·2 years ago

Right, and the hair thing is worth repeating: it tracks the rate of loss rather than the compound, and it stops.

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u/saskia_lokkenOP19 points·2 years ago

Severe, or unpleasant? They are genuinely different questions and the answers diverge.

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u/priya_weiss7 points·2 years ago

the first fortnight after a step is the worst of it, then it settles

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u/long_post_larry70 points·2 years ago

fatigue plus low intake is usually just low intake

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u/blunt_coldbox_202445 points·2 years ago

I would be careful here. "Everyone gets this" is not true, and it makes the people who get something unusual assume they are fine when they should be asking.

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u/blank_injection19 points·2 years ago

Same pattern here. It settled at a stable dose without me doing anything clever.

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u/insulin_syringe_ian63 points·2 years ago·edited

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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u/marta_marchand25 points·2 years ago

the constipation that arrives at week 91 out of nowhere is usually something else

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u/neha_rahimi10 points·2 years ago

a rough fortnight at each step is normal, a rough three months is not

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u/tl_dr_tina191 points·2 years ago

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

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u/rafael_ostergaard280 points·2 years ago

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

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u/rina_bergstrom186 points·2 years ago

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/line_petrov70 points·2 years ago

smaller meals, earlier, is the boring advice that works

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u/kavya_kravchenko60 points·2 years ago

This. A bad fortnight after a step is expected. A bad quarter is a reason to talk to somebody who knows your history.

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u/ahmed_rasmussen35 points·2 years ago

Which day of the week relative to the shot does it hit?

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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