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c/sideeffects·posted 7 months ago by u/janoshik_junkie

what would you tell week-1 you about reflux

Question Receipts ×9 Long Haul ×1

what would you tell week-1 you about reflux. I would rather ask a basic question now than get this wrong quietly for two months.

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

Hair shedding after significant weight loss is a telogen effect that follows the rate of loss. It is not specific to these compounds and it resolves.

If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.

1,445 up / 303 down83% upvoted51 commentsid 1ahuyk11 Dec 2025

51 comments

30 in this archive, depth 6

best — the order this archive was captured in

u/constipation_clubMOD78 points·7 months ago

This one needs a clinician rather than a comment section, and we have said so in the thread rather than removing it.

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u/janoshik_junkieOPindependent tester45 points·7 months ago

This one needs a clinician rather than a comment section, and we have said so in the thread rather than removing it.

Agreed, with the caveat that "usually settles" is not "always settles" and the exceptions should still get asked about properly.

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u/reta_and_regret31 points·7 months ago

Careful with the supplement recommendation. There is no evidence for it here and the mechanism you are proposing does not hold.

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u/signe_villalobos10 points·7 months ago

Is it every week or did it start at a particular dose?

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u/janoshik_junkieOPindependent tester29 points·7 months ago

Mine settled at week 76 and has not come back since, across two more steps.

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u/tomas_broberg72 points·7 months ago

Nothing in this thread is medical advice, including this comment. I am describing a mechanism, not telling anybody what to do about their own week.

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u/food_noise_gonemaintenance96 points·7 months ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

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u/elin_lundgren25 points·7 months ago

Which day of the week relative to the shot does it hit?

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u/rania_marchand8 points·7 months ago

I would be careful here. "Everyone gets this" is not true, and it makes the people who get something unusual assume they are fine when they should be asking.

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u/step_therapy_s4 points·7 months ago

fibre and water before you buy anything to fix it

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u/enzo_danquah29 points·7 months ago

That reads like advice, and none of us can give it. Describe what you did, not what somebody else should do.

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u/elin_lindqvist12 points·7 months ago

That symptom is not the one being described upthread. Two different things with similar names and the answers are not interchangeable.

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[removed]6 points·7 months ago

[removed by moderator]

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u/laila_delgado8 points·7 months ago

Agreed. Slowing down at meals did more for my sulphur burps than everything I bought to fix it, which was embarrassing to discover.

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u/rania_diallo3 points·7 months ago

Not convinced by that mechanism. Slowed gastric emptying explains fullness and reflux; it does not explain what you are describing.

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u/liv_vukovic1 point·7 months ago

Reflux was the one that got me. Stopped eating in the three hours before bed and it went from nightly to almost never.

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u/adaeze_batista9 points·7 months ago

Kept a one-line-a-day log for two months. The pattern was obvious on paper and invisible in my head.

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u/laila_delgado13 points·7 months ago·edited

injection-site soreness for the first eight days after each step, then nothing, every single time. Predictable enough that I started planning my week around it.

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u/rohan_steiner-31 points·7 months ago

the first fortnight after a step is the worst of it, then it settles

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u/aurel_mwangi5 points·7 months ago

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/zeynep_ndiaye4 points·7 months ago

Pushback: you changed the dose, the meal timing and the training in the same fortnight, so the attribution is guesswork.

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u/line_petrov31 points·7 months ago

Held the dose for an extra six weeks instead of stepping. The sulphur burps settled and I lost the same amount anyway.

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u/rafael_ostergaard34 points·7 months ago

Most of the common complaints trace back to slowed gastric emptying — early fullness, reflux, nausea after a large or fatty meal. That is also why meal size and speed change the experience more than anything else.

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u/tomas_broberg10 points·7 months ago

Same pattern here. It settled at a stable dose without me doing anything clever.

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u/ahmed_rasmussen8 points·7 months ago

the fatigue that arrives at week 9 out of nowhere is usually something else

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u/insulin_syringe_ian2 points·7 months ago

hair shedding follows the weight loss, not the drug, and it stops

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u/janoshik_junkieOPindependent tester4 points·7 months ago

Severe, or unpleasant? They are genuinely different questions and the answers diverge.

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Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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