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c/sideeffects·posted 1 months ago by u/fabio_nkemelu

anyone else notice hair loss kicking in around week 21

Resolved Well Actually ×9 Slow Clap ×2

Reporting in. anyone else notice hair loss kicking in around week 21.

The fatigue turned out to be that I was eating about a third of what I thought I was. Tracked it for a week and the mystery evaporated.

Nobody warned me about fatigue and I would have liked the warning. It was not dangerous, it was just deeply unpleasant and completely unexpected.

I will update this if the picture changes rather than quietly leaving it up.

1,325 up / 281 down83% upvoted34 commentsid 18j9gm26 Jun 2026

34 comments

25 in this archive, depth 4

best — the order this archive was captured in

u/marit_coelho157 points·1 months ago

Constipation is mostly reduced intake plus reduced fluid, not a direct effect. That is why the boring fibre and water answer keeps working.

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u/signe_villalobos55 points·1 months ago

Reflux was the one that got me. Stopped eating in the three hours before bed and it went from nightly to almost never.

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u/zeynep_zielinski-34 points·1 months ago

Bought four different things to fix my nausea. What actually worked was eating half as fast.

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u/quiet_moderatorMOD89 points·1 months ago·edited

Left up. It is a description of one person’s week and it is flagged as such.

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u/bastian_eriksen133 points·1 months ago

Disagree. Severe abdominal pain is not on the list of things to wait out, and this board should not be treating it as one.

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u/constipation_clubside effects155 points·1 months ago

Severe or persistent abdominal pain sits outside the pattern this board can usefully discuss. The honest answer there is that it needs someone who can examine you.

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u/insulin_syringe_ian82 points·1 months ago

The pattern almost everyone here describes, written out once so it can be linked.

A step up is followed by a rough window — commonly early fullness arriving the day after the shot and easing by day four, worst in the first fortnight, then flattening out. At a stable dose it usually settles further. Constipation and fatigue tend to track intake and fluid rather than the compound directly, which is why the unglamorous answers work.

What sits outside that pattern: severe pain, symptoms that appear from nowhere weeks into a stable dose, or anything getting worse rather than better over a month. None of that is a board question and none of us can answer it for you.

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u/marit_coelho55 points·1 months ago

How long after a step up did this start?

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u/elin_lindqvist39 points·1 months ago

Careful with the supplement recommendation. There is no evidence for it here and the mechanism you are proposing does not hold.

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u/fabio_nkemeluOP24 points·1 months ago

hair shedding follows the weight loss, not the drug, and it stops

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u/piotr_bruun8 points·1 months ago

fibre and water before you buy anything to fix it

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u/usp_appendixcompendial3 points·1 months ago

This. A bad fortnight after a step is expected. A bad quarter is a reason to talk to somebody who knows your history.

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u/ferritin_low3 points·1 months ago

Agreed on writing it down. I could not see the pattern until I had six weeks of it on one page.

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u/sofia_wikstrom28 points·1 months ago

The effect on gastric emptying is most pronounced early and attenuates with continued dosing, which is the mechanism behind the "it settles at a stable dose" pattern the whole board reports.

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u/emil_barros9 points·1 months ago

eating slower does more than most of the supplements people recommend

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u/thermal_mass_tom5 points·1 months ago

Yes. Holding the dose is a real option and it does not mean you have failed at anything.

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u/fabio_nkemeluOP15 points·1 months ago

Has anything else changed in the same window?

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u/plain_titration_20244 points·1 months ago

the food noise going quiet is the effect people came for, and nausea is the toll for the first fortnight

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u/vendorinvestigate_vic19 points·1 months ago

Keeping a log, and what to put in it.

One line a day: dose, day since injection, what the symptom was and how bad out of five, and roughly what you ate. Two months of that fits on one page and the pattern is obvious on paper in a way it never is in your head.

Mine showed a clean day-two-to-day-four window I had been describing as "random". Once you can see the pattern you can plan around it, and planning around it is most of the relief.

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u/elin_trevino12 points·1 months ago·edited

Small fix — the shedding follows the rate of weight loss, not the compound, and it is temporary.

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u/fatima_asante4 points·1 months ago

reflux at night, try not eating in the three hours before bed

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u/ayesha_radich2 points·1 months ago

reflux at night, try not eating in the three hours before bed

fatima_asante is right about the timing. The day-of-week pattern is the diagnostic bit, not the severity.

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u/blank_injection9 points·1 months ago

Not convinced by that mechanism. Slowed gastric emptying explains fullness and reflux; it does not explain what you are describing.

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u/cormac_danquah17 points·1 months ago

Held the dose for an extra six weeks instead of stepping. The nausea settled and I lost the same amount anyway.

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u/slow_logbook_ftw10 points·1 months ago

On buying things to fix side effects, which I did extensively and would not do again.

The interventions that changed anything for me were all behavioural and free: smaller meals, eating slower, stopping food a few hours before sleep, more fibre and considerably more water. The things I bought did nothing I could detect, and I was motivated to detect something.

The other lever, which people forget, is time at dose. Holding rather than stepping is a legitimate plan and it fixed my tolerance where nothing else did.

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About c/sideeffects

Side-effect experience and management, with a strong bias toward the ones that are common and boring (nausea, constipation, reflux, fatigue, sulphur burps) and a hard line on the ones that are not (severe abdominal pain, persistent vomiting, jaundice, vision changes). This community is not a substitute for urgent care and the mods will say so bluntly.

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