reading weekly dosing threads from 2024 and half of it aged badly
Thinking out loud about this: reading weekly dosing threads from 2024 and half of it aged badly.
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.
Week 45: 20kg down, sulphur burps basically gone since about week 7, and the honest headline is that nothing dramatic happened. It was boring and it worked.
That is everything I have. The rest is opinion and I have tried to keep it out.
best — the order this archive was captured in
The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.
Leaving this up. It is a check-in, it has numbers, and it is honest about being one person.
Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.
Are you measuring anything other than weight? Waist is usually the one that keeps moving.
What I would tell week-one me, in order of how much time it would have saved.
One: the first month is a tolerance check. You are finding out whether you can take this, not how much you will lose. Two: write down the dose, the day and the waist measurement. Three: a stall of under six weeks is weather, not climate. Four: constipation that arrives the day after the shot and fades by day four is the ordinary pattern and it usually settles at a stable dose.
None of that is advice about what you should do. It is the shape of the thing, which nobody explained to me and which the wiki explains better than I just did.
Correct, and worth adding: the trial average is an average. Half the people in it did worse than 15% and were still on the drug.
Minor fix — the half-life is about a week, not about a day. The rest of your point stands.
That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.
the food noise going quiet is the effect people actually describe
Correcting myself from earlier in the thread: I said week 2 and it was week 11. Same shape, wrong number.