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c/semaglutide·submitted 9 months ago by u/dead_space_doug

titration: what the trials say vs what this community says

Titrationbranch of 6 comments

Posting this as a discussion rather than a claim: titration: what the trials say vs what this community says. Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts. Delayed gastric emptying is most pronounced early and…

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6 comments, started 9 months ago
u/niels_lindqvist313 points·9 months ago

The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.

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u/teodor_duarte107 points·9 months ago·edited

Cosigning. The appetite change and the scale change ran about three weeks apart for me too.

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u/helga_vermeulen0 points·9 months ago

Cosigning.

This is the part I would underline for anyone skimming. Everything else in the thread is downstream of it.

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u/leila_silva1 point·9 months ago

nausea that arrives on day two and fades by day four is the standard shape

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u/camila_sandvik-6 points·9 months ago

I would push back gently. Going up because the scale paused is the single most common mistake described on this board.

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u/helga_vermeulen260 points·9 months ago

do not chase somebody else’s titration schedule, they are not you

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