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c/semaglutide·posted 10 months ago by u/two_mil_or_one

Wegovy: what the trials say vs what this community says

Side Effects Sourced ×1 Slow Clap ×3 Receipts ×2

Something I keep coming back to: Wegovy: what the trials say vs what this community says.

reflux made the first fortnight rough at each step up, then flattened out. Predictable enough that I started planning around it.

What I would tell week-one me, in order of how much time it would have saved.

One: the first month is a tolerance check. You are finding out whether you can take this, not how much you will lose. Two: write down the dose, the day and the waist measurement. Three: a stall of under six weeks is weather, not climate. Four: early fullness that arrives the day after the shot and fades by day four is the ordinary pattern and it usually settles at a stable dose.

None of that is advice about what you should do. It is the shape of the thing, which nobody explained to me and which the wiki explains better than I just did.

The appetite thing was the surprise. I expected to feel full. What I got was simply not thinking about food between meals.

Happy to answer the boring questions. Those are usually the ones worth asking.

3,597 up / 323 down92% upvoted56 commentsid dyx2ix7 Sep 2025

56 comments

16 in this archive, depth 4

best — the order this archive was captured in

u/ravi_sandvik517 points·10 months ago

Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the sulphur burps usually fades at a stable dose.

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u/nadia_bakker166 points·10 months ago

Kept a log from week one and the single most useful column turned out to be waist, not weight.

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[deleted]187 points·10 months ago

[deleted]

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u/rania_diallo467 points·10 months ago

Yes. Week 71 is when almost everybody writes the "is it still working" post, and almost everybody is fine.

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u/ines_castellanos-3 points·10 months ago

do not chase somebody else’s titration schedule, they are not you

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u/marta_trevino1 point·10 months ago

Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.

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u/two_mil_or_oneOP1 point·10 months ago

What did week 31 look like compared with this one? The month either side is the useful comparison.

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u/noor_hovland239 points·10 months ago

Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.

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u/diego_sorensen114 points·10 months ago·edited

Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chem

Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.

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u/quiet_moderatorMOD181 points·10 months ago

Leaving this up. It is a check-in, it has numbers, and it is honest about being one person.

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u/customs_seizure_sid90 points·10 months ago

Sceptical of the mechanism you are proposing. Gastric emptying slows, it does not stop, and the timings you describe do not follow from it.

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u/ahmed_abubakar61 points·10 months ago

Disagree. 2.4 is the top of the label, not the goal, and "everyone ends up there" is just survivorship in the posts you read.

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u/zeynep_zielinski63 points·10 months ago

First month I lost almost nothing and nearly quit. Month two and three were where it all happened.

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u/oskar_ibarra26 points·10 months ago

Cosigning. The appetite change and the scale change ran about three weeks apart for me too.

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u/reflux_report133 points·10 months ago

Week 32: 7kg down, early fullness basically gone since about week 6, and the honest headline is that nothing dramatic happened. It was boring and it worked.

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u/marit_coelho70 points·10 months ago·edited

What dose and how many weeks at it before this started?

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