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c/semaglutide·submitted 2 years ago by u/nikhil_teixeira

[Vendor] QYB vs HJ on the same compound, same month — both cleared 99.0%

Questionbranch of 8 comments

QYB vs HJ on the same compound, same month — both cleared 99.0%. One vial, one service, one member paying, which is the only kind of result this board should treat as evidence. 99.0%. Those are measured, not estimated, and not rounded up in my favour. The escalation schedule in the trials existed to keep people on…

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8 comments, started 2 years ago
u/kavya_radich69 points·2 years ago

Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.

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u/anya_salgado29 points·2 years ago·edited

Cosigning. The appetite change and the scale change ran about three weeks apart for me too.

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u/b12_baseline17 points·2 years ago·edited

On the "everybody ends up at 2.4" claim, which comes up every few weeks.

The escalation schedule in the trials was designed to get people to a fixed study dose. Real use is not a trial. The dose that keeps your appetite quiet with side effects you can live with is the dose, and for a lot of people on this board that has been 1.7mg for a very long time.

The counter-argument, which is fair: some people genuinely do need the top of the range, and staying low out of caution costs them months. That is a conversation with someone who knows your history, not with us.

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u/arne_restrepo44 points·2 years ago

First month I lost almost nothing and nearly quit. Month two and three were where it all happened.

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u/nausea_notesside effects44 points·2 years ago

Minor fix — the half-life is about a week, not about a day. The rest of your point stands.

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u/greta_perrin29 points·2 years ago·edited

That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.

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u/adaeze_brandt8 points·2 years ago·edited

if 1.0mg is working there is no prize for going up

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u/two_mil_or_one7 points·2 years ago

Careful. A four-week stall is inside normal variation and treating it as failure is how people escalate for no reason.

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