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c/semaglutide·submitted 2 years ago by u/ravi_sandvik

14 months in and titration is still the thing I get wrong

Side Effectsbranch of 9 comments

Here it is: 14 months in and titration is still the thing I get wrong. One person, one log, no control group, so read it accordingly. Hard numbers: 14 months. Anything softer than that is flagged as an impression. What I would tell week-one me, in order of how much time it would have saved. One: the first month is a…

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9 comments, started 2 years ago
u/tomas_kimani156 points·2 years ago

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.

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u/ravi_sandvikOP100 points·2 years ago

staying at 1.7mg for an extra month is a legitimate plan

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u/ravi_sandvikOP62 points·2 years ago

2.4 is a ceiling, not a target

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u/ewan_tulloch33 points·2 years ago

nausea that arrives on day two and fades by day four is the standard shape

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u/quiet_moderatormod79 points·2 years ago

if 2.4mg is working there is no prize for going up

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u/zofia_lindholm62 points·2 years ago

sema is weekly for a reason, the half-life does the smoothing

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