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c/semaglutide·posted 2 years ago by u/micro_bump_mick

[Question] is 96.2% actually fine or am I being sold a rounding error

Question Sourced ×5 The Quiet One ×1 Long Haul ×1

Short version of the title, which is already short: is 96.2% actually fine or am I being sold a rounding error. Longer version underneath.

Numbers, in the order they matter: 96.2%.

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.

Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.

Corrections welcome, especially the pedantic ones. Pedantry is how this board earns its reputation.

8,817 up / 843 down91% upvoted21 commentsid 7c7lyz6 Dec 2023

21 comments

5 in this archive, depth 3

best — the order this archive was captured in

u/zeynep_weiss1.3k points·2 years ago

The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.

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u/hugo_bergstrom-17 points·2 years ago

What dose and how many weeks at it before this started?

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[deleted]1 point·2 years ago

[deleted]

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u/joaquin_stanescu1 point·2 years ago

Minor fix — the half-life is about a week, not about a day. The rest of your point stands.

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u/sorted_by_new695 points·2 years ago

Strongly agree on protein. It did more for my fatigue than any of the things I bought to fix my fatigue.

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