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c/semaglutide·posted 21 days ago by u/georgi_haddad

oral 50mg vs injectable 2.4 — OASIS 1 numbers are closer than i expected

Titration Slow Clap ×9

Confession thread, sort of.

I went from 1.0mg to 15mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 6 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have injection-site soreness I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 45 reads it before doing the same thing.

751 up / 218 down78% upvoted30 commentsid 1gjtlf9 Jul 2026

30 comments

21 in this archive, depth 5

best — the order this archive was captured in

u/camila_mensa78 points·20 days ago

Right, and the corollary is that stopping escalation does not reset your tolerance, it just pauses the clock.

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u/titration_marshalmod · c/semaglutide26 points·20 days ago

Kept a public log for 10 weeks. The comments are what kept it going, honestly. Accountability from strangers works.

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u/reflux_report18 points·20 days ago

Right, and the corollary is that stopping escalation does not reset your tolerance, it just pauses the clock.

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u/meta_analysis_mo21 points·19 days ago

pens are overpriced, research vials are research grade, same molecule different price

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u/quiet_moderatorMOD40 points·20 days ago

Tracking number removed. It identifies both ends of a shipment.

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u/pavel_nkemelu45 points·21 days ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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[deleted]17 points·21 days ago

[deleted]

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u/teodor_duarte38 points·20 days ago

Every time this gets posted it hits the front page and every time someone has to re-explain it.

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u/viktor_nkemelu11 points·20 days ago

Slight fix: the number was 98.7, not 98.3. Decimal point, but a fairly consequential one.

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u/leila_silva4 points·19 days ago

okay but what dose of sema are you on

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u/georgi_haddadOP5 points·19 days ago

Hard agree. Week 48 me needed this. Week 2 me is nodding smugly.

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u/ferritin_low24 points·20 days ago

the 2.4mg dose is not the target, it is just what the pen goes up to

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u/rohan_steiner6 points·20 days ago

Ozempic versus Wegovy versus research grade is the wrong argument, they are literally the same molecule

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u/camila_sandvik22 points·20 days ago

Tried the split-dose thing for 6 weeks. Felt slightly smoother, lost at exactly the same rate. Went back to weekly.

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u/zofia_lindholm14 points·20 days ago·edited

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/archived_thread_a3 points·20 days ago

the quiet is real. the food noise just stops.

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u/georgi_haddadOP1 point·20 days ago

Kept a public log for 27 weeks. The comments are what kept it going, honestly. Accountability from strangers works.

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u/ffmi_watcher2 points·19 days ago

the quiet is real.

Adding to this: 2.4mg is doing more work than the comment implies.

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u/dose_creep_dan1 point·19 days ago

This matches my experience almost exactly on the Ozempic pens. The titration is the whole point.

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u/ines_castellanos2 points·19 days ago

week 84 and i am still not at maintenance, do not rush the ladder

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u/nikhil_teixeira12 points·20 days ago

okay but what dose of sema are you on

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Everything semaglutide: branded pens, compounded vials, oral formulations and the research-grade material people reconstitute themselves. Titration schedules, side-effect management, plateau troubleshooting and long-term maintenance. Dose questions are welcome; "what dose should I take" answers are not, because nobody here is your prescriber.

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