three years of weekly dosing threads, summarised so you do not have to read them
Something I keep coming back to: three years of weekly dosing threads, summarised so you do not have to read them.
reflux made the first fortnight rough at each step up, then flattened out. Predictable enough that I started planning around it.
What I would tell week-one me, in order of how much time it would have saved.
One: the first month is a tolerance check. You are finding out whether you can take this, not how much you will lose. Two: write down the dose, the day and the waist measurement. Three: a stall of under six weeks is weather, not climate. Four: sulphur burps that arrives the day after the shot and fades by day four is the ordinary pattern and it usually settles at a stable dose.
None of that is advice about what you should do. It is the shape of the thing, which nobody explained to me and which the wiki explains better than I just did.
The weekly interval comes out of the half-life — roughly a week — so you are on a smooth curve rather than a series of spikes. That is also why moving your day slightly does very little.
Corrections welcome, especially the pedantic ones. Pedantry is how this board earns its reputation.
best — the order this archive was captured in
Are you measuring anything other than weight? Waist is usually the one that keeps moving.
week 69 plateau is the most predictable thing in this entire board
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
Weight change and appetite change are different endpoints on different timescales.
This is the part I would underline for anyone skimming. Everything else in the thread is downstream of it.
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.
Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose.
Disagree with this specific line. A pause at 0.5mg is not evidence that 0.5mg has stopped working.
Not convinced. You changed the dose and the week at the same time, so you cannot attribute the change to either.
Do muscle cramps track the day after the shot, or is it there all week?
STEP-1 averaged just under 15% at 68 weeks, so a 10% year is not a failure
Cosigning. The appetite change and the scale change ran about three weeks apart for me too.
the ladder exists because the gut needs the time, not because the pharmacy likes paperwork
This matches me almost exactly, right down to the injection-site soreness showing up on the second day and being gone by the fourth.
Sat at 1.7mg for four months because it was doing the job. Everyone told me to go up. The one time I did, the only thing that changed was the injection-site soreness.
Removed the dose recommendation. You can describe what you did; you cannot tell somebody else what to take.
The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.
The escalation schedule in the trials existed to keep people on the drug.
Adding one thing to this: the appetite effect and the scale run on separate clocks, so both halves can be true at once.
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.
Yes — and the honest version is that most of the "it stopped working" posts turn out to be a normal fortnight of water weight.
stalling at 2.4mg is information, not a verdict
Yes. Week 54 is when almost everybody writes the "is it still working" post, and almost everybody is fine.
Genuine question — is the appetite effect still there, or is it just the scale that has paused?
The appetite thing was the surprise. I expected to feel full. What I got was simply not thinking about food between meals.
protein first, then everything else gets easier
Minor fix — the half-life is about a week, not about a day. The rest of your point stands.
- 1Yes — and the honest version is that most of the "it stopped working" posts…8 comments in this branch · started by u/slow_logbook_notes