small win: 2.4mg stopped being a problem at week 51
Reporting in. small win: 2.4mg stopped being a problem at week 51.
2.4mg and week 51. Those are measured, not estimated, and not rounded up in my favour.
The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.
Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the sulphur burps usually fades at a stable dose.
Would rather be corrected in public than confident in private.
best — the order this archive was captured in
STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.
the appetite signal and the scale move on different clocks
Week 73: 19kg down, constipation basically gone since about week 2, and the honest headline is that nothing dramatic happened. It was boring and it worked.
Retitled to match the body. The original promised a comparison the post does not make.
The appetite thing was the surprise. I expected to feel full. What I got was simply not thinking about food between meals.
sema is weekly for a reason, the half-life does the smoothing