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c/semaglutide·submitted 1 year ago by u/kenji_vasquez

Ozempic: what the trials say vs what this community says

Metabranch of 9 comments

Something I keep coming back to: Ozempic: what the trials say vs what this community says. The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does. STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg.…

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9 comments, started 1 year ago
u/careful_gradient_again190 points·1 year ago

Does fatigue track the day after the shot, or is it there all week?

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[removed]72 points·1 year ago

[removed by moderator]

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u/greta_lokken18 points·1 year ago

This matches me almost exactly, right down to the fatigue showing up on the second day and being gone by the fourth.

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u/ines_castellanos-22 points·1 year ago

Dropped my injection day by two days once because of travel. Nothing happened. The panic was worse than the effect.

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u/ewan_tulloch40 points·1 year ago

Are you measuring anything other than weight? Waist is usually the one that keeps moving.

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u/hamza_weiss16 points·1 year ago

Correct, and worth adding: the trial average is an average. Half the people in it did worse than 15% and were still on the drug.

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u/georgi_haddad24 points·1 year ago

What did week 58 look like compared with this one? The month either side is the useful comparison.

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u/nadia_bakker91 points·1 year ago

Cosigning. The appetite change and the scale change ran about three weeks apart for me too.

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u/careful_gradient_again53 points·1 year ago

staying at 1.0mg for an extra month is a legitimate plan

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