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c/semaglutide·submitted 11 months ago by u/hassan_castellanos

[Discussion] we are measuring food noise at the wrong time and calling it noise

Discussionbranch of 10 comments

we are measuring food noise at the wrong time and calling it noise. Making the case below, and I expect to lose some of it in the comments. injection-site soreness made the first fortnight rough at each step up, then flattened out. Predictable enough that I started planning around it. Dropped my injection day by two…

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10 comments, started 11 months ago
u/leila_silva104 points·11 months ago

Cosigning. The appetite change and the scale change ran about three weeks apart for me too.

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u/niels_lindqvist50 points·11 months ago·edited

Cosigning.

Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.

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u/careful_gradient_again33 points·11 months ago

the food noise going quiet is the effect people actually describe

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u/titration_marshalMOD68 points·11 months ago

Removed the dose recommendation. You can describe what you did; you cannot tell somebody else what to take.

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u/hassan_castellanosOP50 points·11 months ago

dose day drift of a day either way is fine, the curve barely notices

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u/kaplan_meier_kim12 points·11 months ago

Kept a log from week one and the single most useful column turned out to be waist, not weight.

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u/helga_vermeulen5 points·11 months ago

the scale is the least sensitive instrument you own

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u/quiet_moderatormod31 points·11 months ago

dose day drift of a day either way is fine, the curve barely notices

Adding one thing to this: the appetite effect and the scale run on separate clocks, so both halves can be true at once.

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u/dead_space_doug16 points·11 months ago

That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.

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u/archived_thread_a28 points·11 months ago

The mental model that finally made this click for me: there are two curves, and people watch the wrong one.

The first is exposure, which is set by the dose and smoothed by a week-long half-life. It changes when you change the dose and then settles over about a month. The second is body weight, which is exposure filtered through appetite, food, water, sleep, training and the scale itself, and which moves in steps rather than a line.

Almost every "it stopped working" post is somebody watching curve two over a fortnight and drawing conclusions about curve one. If the appetite effect is still there, exposure is fine. Wait the month.

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