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c/semaglutide·posted 11 months ago by u/hassan_castellanos

[Discussion] we are measuring food noise at the wrong time and calling it noise

Discussion Receipts ×8 Slow Clap ×3 Cold Box ×1

we are measuring food noise at the wrong time and calling it noise. Making the case below, and I expect to lose some of it in the comments.

injection-site soreness made the first fortnight rough at each step up, then flattened out. Predictable enough that I started planning around it.

Dropped my injection day by two days once because of travel. Nothing happened. The panic was worse than the effect.

Steady state after a dose change takes four to five half-lives, so the fair judgement point on a new step is about a month, not four days.

If two or three other people have done the same thing we might actually learn something. Alone it is an anecdote.

4,876 up / 550 down90% upvoted55 commentsid 1ebbna11 Aug 2025

55 comments

27 in this archive, depth 5

best — the order this archive was captured in

u/enzo_danquah215 points·11 months ago

Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the reflux usually fades at a stable dose.

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[removed]87 points·11 months ago

[removed by moderator]

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u/endpoint_creep49 points·11 months ago

Careful. A four-week stall is inside normal variation and treating it as failure is how people escalate for no reason.

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u/hassan_castellanosOP18 points·11 months ago

Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.

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u/alcohol_aversion127 points·11 months ago

How long was the stall before you decided it was a stall?

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u/plain_titration187 points·11 months ago

How long was the stall before you decided it was a stall?

Disagree with this specific line. A pause at 0.5mg is not evidence that 0.5mg has stopped working.

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u/slow_logbook_notes194 points·11 months ago·edited

Disagree. 2.4 is the top of the label, not the goal, and "everyone ends up there" is just survivorship in the posts you read.

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u/leila_silva90 points·11 months ago

staying at 1.0mg for an extra month is a legitimate plan

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u/throwaway_titration100 points·11 months ago

protein first, then everything else gets easier

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u/rania_diallo70 points·11 months ago

Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.

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u/leila_silva104 points·11 months ago

Cosigning. The appetite change and the scale change ran about three weeks apart for me too.

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u/niels_lindqvist50 points·11 months ago·edited

Cosigning.

Right, and the timescale is the bit that keeps getting lost. Judge a step at a month, not at a weekend.

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u/careful_gradient_again33 points·11 months ago

the food noise going quiet is the effect people actually describe

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u/titration_marshalMOD68 points·11 months ago

Removed the dose recommendation. You can describe what you did; you cannot tell somebody else what to take.

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u/hassan_castellanosOP50 points·11 months ago

dose day drift of a day either way is fine, the curve barely notices

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u/kaplan_meier_kim12 points·11 months ago

Kept a log from week one and the single most useful column turned out to be waist, not weight.

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u/helga_vermeulen5 points·11 months ago

the scale is the least sensitive instrument you own

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u/quiet_moderatormod31 points·11 months ago

dose day drift of a day either way is fine, the curve barely notices

Adding one thing to this: the appetite effect and the scale run on separate clocks, so both halves can be true at once.

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u/dead_space_doug16 points·11 months ago

That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.

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u/archived_thread_a28 points·11 months ago

The mental model that finally made this click for me: there are two curves, and people watch the wrong one.

The first is exposure, which is set by the dose and smoothed by a week-long half-life. It changes when you change the dose and then settles over about a month. The second is body weight, which is exposure filtered through appetite, food, water, sleep, training and the scale itself, and which moves in steps rather than a line.

Almost every "it stopped working" post is somebody watching curve two over a fortnight and drawing conclusions about curve one. If the appetite effect is still there, exposure is fine. Wait the month.

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u/test_it_yourselfvetting72 points·11 months ago

First month I lost almost nothing and nearly quit. Month two and three were where it all happened.

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u/osman_ferrari37 points·11 months ago

I would push back gently. Going up because the scale paused is the single most common mistake described on this board.

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u/pavel_nkemelu16 points·11 months ago

Same. I sat at 1.0mg for three months because it was working and there was nothing to fix.

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u/archived_thread_a4 points·11 months ago

STEP-1 ran 68 weeks and landed just under 15% mean body weight change on 2.4mg. It is an average of a wide distribution, not a target you have missed.

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u/units_not_mgsyringe math0 points·11 months ago

Not convinced. You changed the dose and the week at the same time, so you cannot attribute the change to either.

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