[PSA] 2.4mg is not what most of this community thinks it is
2.4mg is not what most of this community thinks it is — with the reasoning, because a rule without a reason gets ignored. 2.4mg — those are the numbers, and they are the ones I am willing to defend. The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the…
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.
staying at 0.5mg for an extra month is a legitimate plan
That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.
How long was the stall before you decided it was a stall?
That reads like a titration plan and this board cannot give you one. Somebody who actually knows your history has to.
the first four weeks are a tolerance check, not a weight-loss phase
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
Weight change and appetite change are different endpoints on different timescales.
gradient_goblin is describing the standard shape here and it matches the trial data better than most anecdotes do.