[PSA] 2.4mg is not what most of this community thinks it is
2.4mg is not what most of this community thinks it is — with the reasoning, because a rule without a reason gets ignored.
2.4mg — those are the numbers, and they are the ones I am willing to defend.
The escalation schedule in the trials existed to keep people on the drug. It is a tolerability ramp, and it is why the label reads the way it does.
Delayed gastric emptying is most pronounced early and attenuates with continued dosing, which is why the reflux usually fades at a stable dose.
Would rather be corrected in public than confident in private.
best — the order this archive was captured in
Research-use-only material is not approved for human use, so anything in this thread about how a compounded or research vial "should" behave is a chemistry discussion, not a dosing one.
staying at 0.5mg for an extra month is a legitimate plan
That figure is the 68-week trial mean, not a weekly rate. Dividing it by the weeks gives you a number that does not mean anything.
How long was the stall before you decided it was a stall?
That reads like a titration plan and this board cannot give you one. Somebody who actually knows your history has to.
the first four weeks are a tolerance check, not a weight-loss phase
Weight change and appetite change are different endpoints on different timescales. Conflating them is where most of the confusion on this board starts.
Weight change and appetite change are different endpoints on different timescales.
gradient_goblin is describing the standard shape here and it matches the trial data better than most anecdotes do.
Correct, and worth adding: the trial average is an average. Half the people in it did worse than 15% and were still on the drug.
Small correction: 2.4mg is the maintenance ceiling on the label, not the starting maintenance dose. The distinction matters for anyone reading this later.
dose day drift of a day either way is fine, the curve barely notices
- 1Research-use-only material is not approved for human use, so anything in…8 comments in this branch · started by u/hassan_ostergaard